Carboxylated aurone derivatives as potent inhibitors of xanthine oxidase

• Published in: Bioorganic & medicinal chemistry Vol. 25; no. 14; pp. 3606 - 3613
• Main Authors: Muzychka, Oksana V., Kobzar, Oleksandr L., Popova, Antonina V., Frasinyuk, Mykhaylo S., Vovk, Andriy I.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.07.2017; Elsevier
• Subjects: Aurone derivatives; Benzofurans - chemical synthesis; Benzofurans - chemistry; Benzofurans - metabolism; Binding Sites; Biochemistry & Molecular Biology; Carboxylic Acids - chemistry; Catalytic Domain; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Enzyme inhibition; Enzyme Inhibitors - chemical synthesis; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - metabolism; Inhibitory Concentration 50; Kinetics; Life Sciences & Biomedicine; Molecular docking; Molecular Docking Simulation; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; Structure-Activity Relationship; Xanthine oxidase; Xanthine Oxidase - antagonists & inhibitors; Xanthine Oxidase - metabolism; Enzyme inhibition; Aurone derivatives; Xanthine oxidase; Structure-activity relationship; Molecular docking; DESIGN; MECHANISM; MOLYBDENUM; OXIDOREDUCTASE; FLAVONOIDS; SCAVENGERS; DISCOVERY; ENZYMES; AGENTS; SCAFFOLD

[Display omitted] •Carboxylated aurone derivatives are able to inhibit xanthine oxidase in vitro.•The inhibition efficiency of the aurone derivatives is higher than that of sulfuretin.•Modes of inhibitor binding to the enzyme active site are proposed. Xanthine oxidase is a potential target for treat...