Synthetic tambjamine analogues induce mitochondrial swelling and lysosomal dysfunction leading to autophagy blockade and necrotic cell death in lung cancer - Rodilla, Ananda M.; Korrodi-Gregório, Luís; Hernando, Elsa; Manuel-Manresa, Pilar; Quesada, Roberto; Pérez-Tomás, Ricardo; Soto-Cerrato, Vanessa (Biochemical pharmacology, 2017)
Keywords: Alkaloids - chemical synthesis; Alkaloids - pharmacology; Anionophores; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Autophagy - drug effects; Autophagy blockade; Cell Line, Tumor; Humans; Hydrogen-Ion Concentration; Ionophores - pharmacology; Lysosomal dysfunction; Lysosomes - drug effects; Lysosomes - metabolism; Mitochondria - drug effects; Mitochondria - pathology; Mitochondrial Size; Necrosis; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - pathology; Pyrroles - chemical synthesis; Pyrroles - pharmacology; Synthetic tambjamine analogues; Anionophores; Lysosomal dysfunction; Synthetic tambjamine analogues; Autophagy blockade; Necrosis