Self-assembling protein platform for direct quantification of circulating microRNAs in serum with total internal reflection fluorescence microscopy

• Published in: Analytica chimica acta Vol. 823; pp. 61 - 68
• Main Authors: Ho, See-Lok, Chan, Ho-Man, Wong, Ricky Ngok-Shun, Li, Hung-Wing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2014
• Subjects: Humans; MicroRNAs - blood; Microscopy, Fluorescence - methods; Nanostructures - chemistry; Sensitivity and Specificity

[Display omitted] •Direct, specific and highly sensitive yet simple detection assay for circulating miRNA in serum.•Ultrasensitive detection with trace amount of sample consumption.•Self-assembled protein nanofibril acts as an online pre-concentrating platform. MicroRNA (miRNA) has recently emerged...