Phenotype- and species-specific skin proteomic signatures for incision-induced pain in humans and mice

• Published in: British journal of anaesthesia : BJA Vol. 130; no. 3; pp. 331 - 342
• Main Authors: Segelcke, Daniel, van der Burgt, Max, Kappert, Christin, Schmidt Garcia, Daniela, Sondermann, Julia R., Bigalke, Stephan, Pradier, Bruno, Gomez-Varela, David, Zahn, Peter K., Schmidt, Manuela, Pogatzki-Zahn, Esther M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2023
• Subjects: acute pain; Animals; chronic pain; chronic post-surgical pain; Humans; Hyperalgesia - prevention & control; incision; Male; Mice; Pain, Postoperative; phenotype; protein-protein interaction; Proteome; Proteomics; Skin - metabolism; surgical pain; translational; phenotype; chronic pain; proteomics; translational; acute pain; chronic post-surgical pain; incision; protein-protein interaction; surgical pain

Acute pain after surgery is common and often leads to chronic post-surgical pain, but neither treatment nor prevention is currently sufficient. We hypothesised that specific protein networks (protein-protein interactions) are relevant for pain after surgery in humans and mice. Standardised surgical...