microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts

• Published in: Clinical science (1979) Vol. 126; no. 6; pp. 417 - 423
• Main Authors: Vaira, Valentina, Roncoroni, Leda, Barisani, Donatella, Gaudioso, Gabriella, Bosari, Silvano, Bulfamante, Gaetano, Doneda, Luisa, Conte, Dario, Tomba, Carolina, Bardella, Maria Teresa, Ferrero, Stefano, Locatelli, Martina, Elli, Luca
• Format: Journal Article
• Language: English
• Published: England 01.03.2014
• Subjects: Adult; Anemia, Iron-Deficiency - etiology; Case-Control Studies; Celiac Disease - complications; Celiac Disease - diagnosis; Celiac Disease - genetics; Celiac Disease - pathology; Cells, Cultured; Diagnosis, Differential; Duodenum - metabolism; Female; Fibroblasts - metabolism; Gene Expression Profiling - methods; Gene Expression Regulation - drug effects; Gliadin - pharmacology; Humans; Intestinal Mucosa - metabolism; Male; MicroRNAs - biosynthesis; MicroRNAs - genetics; Middle Aged; Oligonucleotide Array Sequence Analysis - methods; Phenotype

CD (coeliac disease) is a frequent autoimmune disorder of the small bowel, which is characterized by an immunological reaction against gluten and transglutaminase in genetically predisposed subjects. However, the molecular determinants underpinning CD pathogenesis are yet to be fully elucidated and...