A novel modified physiologically relevant model for cardiac angiogenesis

• Published in: Microvascular research Vol. 114; pp. 84 - 91
• Main Authors: Zhang, Hao, Pan, Jiajun, Qiu, Fan, Wei, Tengteng, Li, Zhimin, Jiang, Xia, Zhuang, Wei, Liu, Zhiwei, Zhang, Zhongming, Dong, Hongyan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2017
• Subjects: Angiogenesis; Angiogenesis Inducing Agents - pharmacology; Angiogenesis Inhibitors - pharmacology; Animals; Animals, Newborn; Cardiac explants; Cell Hypoxia; Cellular Microenvironment; Collagen - metabolism; Coronary Vessels - drug effects; Coronary Vessels - metabolism; Coronary Vessels - physiology; Drug Combinations; Fibronectin; Fibronectins - metabolism; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - physiology; Humans; HUVECs; Laminin - metabolism; Matrigel; Neovascularization, Physiologic - drug effects; Proteoglycans - metabolism; Rats, Sprague-Dawley; Time Factors; Tissue Culture Techniques; Angiogenesis; Cardiac explants; Fibronectin; HUVECs; Matrigel

Angiogenesis assays are important tools for studying both the mechanisms of cardiac angiogenesis and the potential development of therapeutic strategies to ischemic heart diseases. Currently, various assays have been used to quantitate cardiac tubule formation, yet no consensus has been reached rega...