Structural and Functional Alterations Caused by Aureobasidin A in Clinical Resistant Strains of Candida spp

• Published in: Journal of fungi (Basel) Vol. 9; no. 11; p. 1115
• Main Authors: Rollin-Pinheiro, Rodrigo, de Moraes, Daniel, Bayona-Pacheco, Brayan, Curvelo, Jose, dos Santos-Freitas, Giulia, Xisto, Mariana, Borba-Santos, Luana, Rozental, Sonia, Ferreira-Pereira, Antonio, Barreto-Bergter, Eliana
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2023
• Subjects: Amphotericin B; Antifungal activity; Antifungal agents; aureobasidin A; Biofilms; Biosynthesis; Candida; Enzymes; Fluconazole; fungal infection; Fungal infections; Fungi; Lipids; membrane; Membrane potential; Metabolism; Oxidative stress; Sodium lauryl sulfate; Sphingolipids; Structure-function relationships; Virulence; St Louis Missouri; United States > US

Candida species are one of the most concerning causative agents of fungal infections in humans. The treatment of invasive Candida infections is based on the use of fluconazole, but the emergence of resistant isolates has been an increasing concern which has led to the study of alternative drugs with...