Lead exposure inhibits osteoblastic differentiation and inactivates the canonical Wnt signal and recovery by icaritin in MC3T3-E1 subclone 14 cells

• Published in: Chemico-biological interactions Vol. 303; pp. 7 - 13
• Main Authors: Sun, Kehuan, Mei, Wenhui, Mo, Shu, Xin, Ling, Lei, Xiaojun, Huang, Mengtian, Chen, Qiufang, Han, Li, Zhu, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 25.04.2019
• Subjects: Canonical wnt pathway; Icaritin; Lead; Osteoblastic differentiation; Osteoblastic differentiation; Canonical wnt pathway; Lead; Icaritin

Exposure to lead (Pb) poses a threat to human bone health, including changes in bone mineral composition and the inhibition of skeletal growth and bone maturation. However, little is known about how Pb directly affects osteoblasts. In this work, we found that sub-toxic Pb concentrations suppressed b...