Social impairments in mice lacking the voltage-gated potassium channel Kv3.1

• Published in: Behavioural brain research Vol. 413; p. 113468
• Main Authors: Bee, Sarah, Ringland, Amanda, Coutellier, Laurence
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.09.2021
• Subjects: Animals; Autism; Autism Spectrum Disorder - metabolism; Autism Spectrum Disorder - physiopathology; Behavior, Animal - physiology; Behavioral Symptoms - metabolism; Behavioral Symptoms - physiopathology; Corpus Striatum - metabolism; Corpus Striatum - physiopathology; Disease Models, Animal; Kv3.1 channel; Mice; Mice, Knockout; Parvalbumin; Parvalbumins - metabolism; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiopathology; Psychomotor Agitation - metabolism; Psychomotor Agitation - physiopathology; Shaw Potassium Channels - deficiency; Social Behavior; Stereotyped Behavior - physiology; Autism; Mice; Social behavior; Parvalbumin; Kv3.1 channel

•Mice deficient in the Kv3.1 voltage-dependent potassium channel display social deficits.•Mice deficient in the Kv3.1 channel display hyperactivity.•Mice deficient in the Kv3.1 channel have abnormal expression of parvalbumin in the striatum and prefrontal cortex. Parvalbumin (PV)-expressing neurons...