Role of extracellular vesicles in glioma progression

The role of extracellular vesicles in cancer biology has emerged as a focus of the study of great importance and has been shown to directly influence tumour development in several cancers including brain tumours, such as gliomas. Gliomas are the most aggressive brain tumours, and in the last time, a...

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Published inMolecular aspects of medicine Vol. 60; pp. 38 - 51
Main Authors Quezada, Claudia, Torres, Ángelo, Niechi, Ignacio, Uribe, Daniel, Contreras-Duarte, Susana, Toledo, Fernando, San Martín, Rody, Gutiérrez, Jaime, Sobrevia, Luis
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2018
Subjects
Apoptotic bodies
Exosomes
Extracellular vesicles
Glioblastoma
Glioma
Large oncosomes
Microvesicles
Glioma
Apoptotic bodies
Glioblastoma
Extracellular vesicles
Microvesicles
Exosomes
Large oncosomes
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Summary:The role of extracellular vesicles in cancer biology has emerged as a focus of the study of great importance and has been shown to directly influence tumour development in several cancers including brain tumours, such as gliomas. Gliomas are the most aggressive brain tumours, and in the last time, a considerable effort has been made to understand their biology. Studies focus in the signalling pathways involved in the processes of angiogenesis, viability, drug resistance and immune response evasion, as well as gliomas ability to infiltrate healthy tissue, a phenomenon regulated by the migratory and invasive capacity of the cells within a tumour. In this review, we summarize the different types and classifications of extracellular vesicles, their intravesicular content, and their role in the regulation of tumour progression processes in glioma.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0098-2997
1872-9452
DOI:10.1016/j.mam.2017.12.003