The ubiquitin-like (UBX)-domain-containing protein Ubx2/ Ubxd8 regulates lipid droplet homeostasis

• Published in: Journal of cell science Vol. 125; no. Pt 12; p. 2930
• Main Authors: Wang, Chao-Wen, Lee, Shu-Chuan
• Format: Journal Article
• Language: English
• Published: England 15.06.2012
• Subjects: Blood Proteins - genetics; Blood Proteins - metabolism; Carrier Proteins - chemistry; Carrier Proteins - genetics; Carrier Proteins - metabolism; Genetic Complementation Test; Homeostasis; Humans; Lipid Metabolism; Membrane Proteins - chemistry; Membrane Proteins - genetics; Membrane Proteins - metabolism; Organelles - genetics; Organelles - metabolism; Protein Structure, Tertiary; Protein Transport; Saccharomyces cerevisiae - chemistry; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - chemistry; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism

Lipid droplets (LDs) are central organelles for maintaining lipid homeostasis. However, how cells control the size and number of LDs remains largely unknown. Herein, we report that Ubx2, a UBX-domain-containing protein involved in endoplasmic reticulum (ER)-associated degradation (ERAD), is crucial...