Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania
The bioactive signaling lipid sphingosine-1-phosphate (S1P) is a potential biomarker for cardiovascular disease (CVD). To date, no reference intervals for S1P have been defined. This study aims to establish a reference range for serum S1P in healthy individuals. We determined reference intervals for...
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| Published in | Clinica chimica acta Vol. 468; pp. 25 - 31 |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier B.V
01.05.2017
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| Abstract | The bioactive signaling lipid sphingosine-1-phosphate (S1P) is a potential biomarker for cardiovascular disease (CVD). To date, no reference intervals for S1P have been defined. This study aims to establish a reference range for serum S1P in healthy individuals.
We determined reference intervals for S1P levels according to gender and age in a sample of 1339 healthy participants of the Study of Health in Pomerania (SHIP)-TREND cohort after exclusion of subjects with CVD, diabetes mellitus, hypertension, metabolic syndrome, elevated liver enzymes, chronic kidney disease stadium III or IV, or body mass index (BMI)>30kg/m2. Serum S1P was measured by liquid chromatography-tandem mass spectrometry.
The median age of the participants was 41 (25th; 75th percentile 32; 51) years, 65% were women. The median serum concentration of S1P was 0.804 (0.694; 0.920) μmol/L. No association with gender and age was observed. The overall reference interval was 0.534–1.242μmol/L (2.5th; 97.5th percentile). Further exclusion of smokers, individuals with BMI>25kg/m2 or elevated lipid levels did not significantly affect median S1P concentrations.
This study provides reference intervals for serum S1P in healthy individuals. Total serum S1P concentrations vary irrespectively of age, gender, BMI or smoking status.
•We provide for the first time a reference range for S1P in healthy individuals.•The reference range in serum is 0.534–1.242μmol/L (2.5th; 97.5th percentile).•Serum levels of S1P do neither depend on gender nor on age.•The reference range may enable individual cardiovascular risk progression. |
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| AbstractList | The bioactive signaling lipid sphingosine-1-phosphate (S1P) is a potential biomarker for cardiovascular disease (CVD). To date, no reference intervals for S1P have been defined. This study aims to establish a reference range for serum S1P in healthy individuals.
We determined reference intervals for S1P levels according to gender and age in a sample of 1339 healthy participants of the Study of Health in Pomerania (SHIP)-TREND cohort after exclusion of subjects with CVD, diabetes mellitus, hypertension, metabolic syndrome, elevated liver enzymes, chronic kidney disease stadium III or IV, or body mass index (BMI)>30kg/m2. Serum S1P was measured by liquid chromatography-tandem mass spectrometry.
The median age of the participants was 41 (25th; 75th percentile 32; 51) years, 65% were women. The median serum concentration of S1P was 0.804 (0.694; 0.920) μmol/L. No association with gender and age was observed. The overall reference interval was 0.534–1.242μmol/L (2.5th; 97.5th percentile). Further exclusion of smokers, individuals with BMI>25kg/m2 or elevated lipid levels did not significantly affect median S1P concentrations.
This study provides reference intervals for serum S1P in healthy individuals. Total serum S1P concentrations vary irrespectively of age, gender, BMI or smoking status.
•We provide for the first time a reference range for S1P in healthy individuals.•The reference range in serum is 0.534–1.242μmol/L (2.5th; 97.5th percentile).•Serum levels of S1P do neither depend on gender nor on age.•The reference range may enable individual cardiovascular risk progression. The bioactive signaling lipid sphingosine-1-phosphate (S1P) is a potential biomarker for cardiovascular disease (CVD). To date, no reference intervals for S1P have been defined. This study aims to establish a reference range for serum S1P in healthy individuals. We determined reference intervals for S1P levels according to gender and age in a sample of 1339 healthy participants of the Study of Health in Pomerania (SHIP)-TREND cohort after exclusion of subjects with CVD, diabetes mellitus, hypertension, metabolic syndrome, elevated liver enzymes, chronic kidney disease stadium III or IV, or body mass index (BMI)>30kg/m . Serum S1P was measured by liquid chromatography-tandem mass spectrometry. The median age of the participants was 41 (25th; 75th percentile 32; 51) years, 65% were women. The median serum concentration of S1P was 0.804 (0.694; 0.920) μmol/L. No association with gender and age was observed. The overall reference interval was 0.534-1.242μmol/L (2.5th; 97.5th percentile). Further exclusion of smokers, individuals with BMI>25kg/m or elevated lipid levels did not significantly affect median S1P concentrations. This study provides reference intervals for serum S1P in healthy individuals. Total serum S1P concentrations vary irrespectively of age, gender, BMI or smoking status. The bioactive signaling lipid sphingosine-1-phosphate (S1P) is a potential biomarker for cardiovascular disease (CVD). To date, no reference intervals for S1P have been defined. This study aims to establish a reference range for serum S1P in healthy individuals.BACKGROUNDThe bioactive signaling lipid sphingosine-1-phosphate (S1P) is a potential biomarker for cardiovascular disease (CVD). To date, no reference intervals for S1P have been defined. This study aims to establish a reference range for serum S1P in healthy individuals.We determined reference intervals for S1P levels according to gender and age in a sample of 1339 healthy participants of the Study of Health in Pomerania (SHIP)-TREND cohort after exclusion of subjects with CVD, diabetes mellitus, hypertension, metabolic syndrome, elevated liver enzymes, chronic kidney disease stadium III or IV, or body mass index (BMI)>30kg/m2. Serum S1P was measured by liquid chromatography-tandem mass spectrometry.METHODSWe determined reference intervals for S1P levels according to gender and age in a sample of 1339 healthy participants of the Study of Health in Pomerania (SHIP)-TREND cohort after exclusion of subjects with CVD, diabetes mellitus, hypertension, metabolic syndrome, elevated liver enzymes, chronic kidney disease stadium III or IV, or body mass index (BMI)>30kg/m2. Serum S1P was measured by liquid chromatography-tandem mass spectrometry.The median age of the participants was 41 (25th; 75th percentile 32; 51) years, 65% were women. The median serum concentration of S1P was 0.804 (0.694; 0.920) μmol/L. No association with gender and age was observed. The overall reference interval was 0.534-1.242μmol/L (2.5th; 97.5th percentile). Further exclusion of smokers, individuals with BMI>25kg/m2 or elevated lipid levels did not significantly affect median S1P concentrations.RESULTSThe median age of the participants was 41 (25th; 75th percentile 32; 51) years, 65% were women. The median serum concentration of S1P was 0.804 (0.694; 0.920) μmol/L. No association with gender and age was observed. The overall reference interval was 0.534-1.242μmol/L (2.5th; 97.5th percentile). Further exclusion of smokers, individuals with BMI>25kg/m2 or elevated lipid levels did not significantly affect median S1P concentrations.This study provides reference intervals for serum S1P in healthy individuals. Total serum S1P concentrations vary irrespectively of age, gender, BMI or smoking status.CONCLUSIONSThis study provides reference intervals for serum S1P in healthy individuals. Total serum S1P concentrations vary irrespectively of age, gender, BMI or smoking status. |
| Author | Wegner, Danilo Rauch, Bernhard H. Felix, Stephan B. Oswald, Stefan Dörr, Marcus Ittermann, Till Schwedhelm, Edzard Böger, Rainer H. Friedrich, Nele Daum, Günter Bahls, Martin Nauck, Matthias Groß, Stefan Moritz, Eileen |
| Author_xml | – sequence: 1 givenname: Eileen surname: Moritz fullname: Moritz, Eileen organization: Institute of Pharmacology, Department of General Pharmacology, University Medicine Greifswald, Germany – sequence: 2 givenname: Danilo surname: Wegner fullname: Wegner, Danilo organization: Institute of Pharmacology, Department of Clinical Pharmacology, University Medicine Greifswald, Germany – sequence: 3 givenname: Stefan surname: Groß fullname: Groß, Stefan organization: Department of Internal Medicine B, University Medicine Greifswald, Germany – sequence: 4 givenname: Martin surname: Bahls fullname: Bahls, Martin organization: Department of Internal Medicine B, University Medicine Greifswald, Germany – sequence: 5 givenname: Marcus surname: Dörr fullname: Dörr, Marcus organization: Department of Internal Medicine B, University Medicine Greifswald, Germany – sequence: 6 givenname: Stephan B. surname: Felix fullname: Felix, Stephan B. organization: Department of Internal Medicine B, University Medicine Greifswald, Germany – sequence: 7 givenname: Till surname: Ittermann fullname: Ittermann, Till organization: German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Germany – sequence: 8 givenname: Stefan surname: Oswald fullname: Oswald, Stefan organization: Institute of Pharmacology, Department of Clinical Pharmacology, University Medicine Greifswald, Germany – sequence: 9 givenname: Matthias surname: Nauck fullname: Nauck, Matthias organization: German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Germany – sequence: 10 givenname: Nele surname: Friedrich fullname: Friedrich, Nele organization: German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Germany – sequence: 11 givenname: Rainer H. surname: Böger fullname: Böger, Rainer H. organization: Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Germany – sequence: 12 givenname: Günter surname: Daum fullname: Daum, Günter organization: German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany – sequence: 13 givenname: Edzard surname: Schwedhelm fullname: Schwedhelm, Edzard organization: Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Germany – sequence: 14 givenname: Bernhard H. surname: Rauch fullname: Rauch, Bernhard H. email: Bernhard.Rauch@uni-greifswald.de organization: Institute of Pharmacology, Department of General Pharmacology, University Medicine Greifswald, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28159438$$D View this record in MEDLINE/PubMed |
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| Keywords | ALAT BP HDL LC-MS/MS QC S1P LDL Sphingosine-1-phosphate SHIP CKD-EPI HbA1c HPLC BMI eGFR ATC code CI CAD IQR Study of Health in Pomerania Reference intervals CVD CV GGT FCS ASAT |
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| Snippet | The bioactive signaling lipid sphingosine-1-phosphate (S1P) is a potential biomarker for cardiovascular disease (CVD). To date, no reference intervals for S1P... |
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| SubjectTerms | Adult Blood Chemical Analysis - standards Female Germany Health Surveys Humans Lysophospholipids - blood Male Reference intervals Sphingosine - analogs & derivatives Sphingosine - blood Sphingosine-1-phosphate Study of Health in Pomerania |
| Title | Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania |
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