Correlation of EGFR gene amplification with invasion and metastasis of non-small cell lung cancer

• Published in: Genetics and molecular research Vol. 14; no. 3; pp. 11006 - 11012
• Main Authors: Jia, X.F., Li, J., Zhao, H.B., Liu, J., Liu, J.J.
• Format: Journal Article
• Language: English
• Published: Brazil 21.09.2015
• Subjects: Adult; Aged; Carcinoma, Non-Small-Cell Lung - enzymology; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; China; Female; Gene Amplification; Genes, erbB-1; Genetic Association Studies; Humans; In Situ Hybridization, Fluorescence; Lung Neoplasms - enzymology; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Middle Aged; Mutation; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Receptor, Epidermal Growth Factor - genetics; China

The aim of this study was to explore epidermal growth factor receptor (EGFR) gene amplification and its relationship with cancer invasion and metastasis in non-small cell lung cancer (NSCLC). EGFR amplification in 45 patients with NSCLC and 15 subjects with normal lung tissues was detected by fluore...