Supramolecular association of 2D alumino-siloxane aquagel building blocks to 3D porous cages and its efficacy for topical and injectable delivery of fluconazole, an antifungal drug
The supramolecular assembly of stimuli-responsive gels is renowned in organic, polymeric and biological systems, but it is seldom reported in inorganic gel systems. Here we report the inorganic system alumino-siloxane (ALS) aquagel by sol-gel synthesis that shows a unique mechano-responsive property...
Saved in:
Published in | Journal of materials chemistry. B, Materials for biology and medicine Vol. 3; no. 29; pp. 5978 - 5990 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
07.08.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The supramolecular assembly of stimuli-responsive gels is renowned in organic, polymeric and biological systems, but it is seldom reported in inorganic gel systems. Here we report the inorganic system alumino-siloxane (ALS) aquagel by sol-gel synthesis that shows a unique mechano-responsive property with an impressive recovery rate. An assembly of 2D nanoribbon/tape like structural architectures was distinctively identified as the primary building block of the aquagel structure. This fascinating 2D architecture self-assembled into a well-defined 3D porous aquagel cage via weak supramolecular interactions. This is identified to be an excellently mechanically stable, injectable and non-cytotoxic medium for drug delivery applications. The ALS aquagel can also overcome the untoward effects caused by photoinitiators, chemical cross-linking agents and organic solvents in organo/polymeric gels when it is used for biomedical applications. Herein, we successfully utilized the ALS inorganic aquagel for the encapsulation and sustained release of fluconazole (FLZ), an antifungal drug, for the first time. The FLZ loaded aquagel showed good antifungal susceptibility against various fungi species, such as Candida albicans, Candida tropicalis and Trichophyton rubrum. The FLZ-ALS aquagel showed an eight-fold enhancement in antifungal susceptibility against the most threatening Candida fungi species when compared to the marketed formulation. |
---|---|
AbstractList | The supramolecular assembly of stimuli-responsive gels is renowned in organic, polymeric and biological systems, but it is seldom reported in inorganic gel systems. Here we report the inorganic system alumino-siloxane (ALS) aquagel by sol-gel synthesis that shows a unique mechano-responsive property with an impressive recovery rate. An assembly of 2D nanoribbon/tape like structural architectures was distinctively identified as the primary building block of the aquagel structure. This fascinating 2D architecture self-assembled into a well-defined 3D porous aquagel cage viaweak supramolecular interactions. This is identified to be an excellently mechanically stable, injectable and non-cytotoxic medium for drug delivery applications. The ALS aquagel can also overcome the untoward effects caused by photoinitiators, chemical cross-linking agents and organic solvents in organo/polymeric gels when it is used for biomedical applications. Herein, we successfully utilized the ALS inorganic aquagel for the encapsulation and sustained release of fluconazole (FLZ), an antifungal drug, for the first time. The FLZ loaded aquagel showed good antifungal susceptibility against various fungi species, such as Candida albicans, Candida tropicalisand Trichophyton rubrum. The FLZ-ALS aquagel showed an eight-fold enhancement in antifungal susceptibility against the most threatening Candidafungi species when compared to the marketed formulation. The supramolecular assembly of stimuli-responsive gels is renowned in organic, polymeric and biological systems, but it is seldom reported in inorganic gel systems. Here we report the inorganic system alumino-siloxane (ALS) aquagel by sol–gel synthesis that shows a unique mechano-responsive property with an impressive recovery rate. An assembly of 2D nanoribbon/tape like structural architectures was distinctively identified as the primary building block of the aquagel structure. This fascinating 2D architecture self-assembled into a well-defined 3D porous aquagel cage via weak supramolecular interactions. This is identified to be an excellently mechanically stable, injectable and non-cytotoxic medium for drug delivery applications. The ALS aquagel can also overcome the untoward effects caused by photoinitiators, chemical cross-linking agents and organic solvents in organo/polymeric gels when it is used for biomedical applications. Herein, we successfully utilized the ALS inorganic aquagel for the encapsulation and sustained release of fluconazole (FLZ), an antifungal drug, for the first time. The FLZ loaded aquagel showed good antifungal susceptibility against various fungi species, such as Candida albicans , Candida tropicalis and Trichophyton rubrum . The FLZ–ALS aquagel showed an eight-fold enhancement in antifungal susceptibility against the most threatening Candida fungi species when compared to the marketed formulation. The supramolecular assembly of stimuli-responsive gels is renowned in organic, polymeric and biological systems, but it is seldom reported in inorganic gel systems. Here we report the inorganic system alumino-siloxane (ALS) aquagel by sol-gel synthesis that shows a unique mechano-responsive property with an impressive recovery rate. An assembly of 2D nanoribbon/tape like structural architectures was distinctively identified as the primary building block of the aquagel structure. This fascinating 2D architecture self-assembled into a well-defined 3D porous aquagel cage via weak supramolecular interactions. This is identified to be an excellently mechanically stable, injectable and non-cytotoxic medium for drug delivery applications. The ALS aquagel can also overcome the untoward effects caused by photoinitiators, chemical cross-linking agents and organic solvents in organo/polymeric gels when it is used for biomedical applications. Herein, we successfully utilized the ALS inorganic aquagel for the encapsulation and sustained release of fluconazole (FLZ), an antifungal drug, for the first time. The FLZ loaded aquagel showed good antifungal susceptibility against various fungi species, such as Candida albicans, Candida tropicalis and Trichophyton rubrum. The FLZ-ALS aquagel showed an eight-fold enhancement in antifungal susceptibility against the most threatening Candida fungi species when compared to the marketed formulation. |
Author | Kumar, Dileep B S Vazhayal, Linsha Talasila, Sindhoor Solaiappan, Ananthakumar Kumar Sasidharan, Nishanth |
Author_xml | – sequence: 1 givenname: Linsha surname: Vazhayal fullname: Vazhayal, Linsha email: ananthakumar70@gmail.com organization: Functional Materials Section, Materials Science and Technology Division, Council of Scientific and Industrial Research-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram-695019, Kerala, India. ananthakumar70@gmail.com – sequence: 2 givenname: Nishanth surname: Kumar Sasidharan fullname: Kumar Sasidharan, Nishanth – sequence: 3 givenname: Sindhoor surname: Talasila fullname: Talasila, Sindhoor – sequence: 4 givenname: Dileep B S surname: Kumar fullname: Kumar, Dileep B S – sequence: 5 givenname: Ananthakumar surname: Solaiappan fullname: Solaiappan, Ananthakumar |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32262654$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkctuFDEQRS0URELIhg9AXiJEg5_dPUsy4SVFYkGQ2LXKr5GD2-7YbcTwXXwgDhOyhZIlu-RT5fK9j9FRTNEi9JSSV5TwzWstV0VIz6R6gE4YkaQbJB2P7s_k6zE6K-WatBhpP3LxCB1zxnrWS3GCfn2uS4Y5BatrgIyhlKQ9rD5FnBxmFxhCnX1MXfEh_YBoMdxU2NmAVfXB-LjDKiT9reA1YX6Bl5RTLVg3pGCIBvu1YOuc16D32KXcuKUl4XAZr61eQQWLjQ3-u83722ddqDpF-NnGetm4tlbvaty1KpPr7gl66CAUe3a3n6Iv795ebT90l5_ef9y-uew0l3ztqNQDcyMY1oQyg7JCWiKcksZobUFxMQggrAfJhWCbFsaMPRFmVJLQzchP0fND3yWnm2rLOs2-aBtCk6F9cmJ8HJqKQvb_ROnAm0uCcvEfaHOu76lkDX1xQHVOpWTrpiX7GfJ-omS6tX_ayqvzP_afN_jZXd-qZmvu0b9m8981X65t |
CitedBy_id | crossref_primary_10_1021_acsami_8b18307 crossref_primary_10_1002_slct_201702674 crossref_primary_10_1016_j_matchemphys_2021_125587 crossref_primary_10_1021_acssuschemeng_6b00821 crossref_primary_10_1088_2053_1591_ab3097 |
Cites_doi | 10.1038/nnano.2008.270 10.1103/PhysRevB.48.15626 10.1021/am505479z 10.1002/adfm.200700587 10.1021/la802234x 10.1021/sc400352a 10.1021/nn5020787 10.1002/bab.1116 10.1039/C0CC04285D 10.1021/jp1111394 10.1023/A:1018568418302 10.1021/am8000456 10.1039/b400922c 10.1038/srep04593 10.1021/ja038521k 10.1021/cm302318b 10.1016/0731-7085(95)01598-1 10.1039/c3sm27050e 10.1007/BF00754473 10.1021/ja503363v 10.1021/la301917e 10.1021/jp049485u 10.1021/la901869t 10.1039/c0jm00491j 10.1055/s-0039-1697442 10.1039/b914062j 10.1021/ja106095w 10.1016/j.ejpb.2011.05.006 10.1039/c3cs60030k 10.1002/jrs.736 10.1021/bm5000423 10.1039/c3ta14665k 10.1039/c2sm07309a 10.1039/C1SM06708G 10.1016/j.carbon.2012.02.083 10.1021/mp400615n 10.1021/ja063408q 10.1021/cm702141e 10.1021/bm100980w 10.1016/j.cej.2014.07.137 |
ContentType | Journal Article |
DBID | NPM AAYXX CITATION M7N 7QF 7SR 7U5 8BQ 8FD JG9 L7M 7X8 |
DOI | 10.1039/c5tb00625b |
DatabaseName | PubMed CrossRef Algology Mycology and Protozoology Abstracts (Microbiology C) Aluminium Industry Abstracts Engineered Materials Abstracts Solid State and Superconductivity Abstracts METADEX Technology Research Database Materials Research Database Advanced Technologies Database with Aerospace MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef Algology Mycology and Protozoology Abstracts (Microbiology C) Materials Research Database Engineered Materials Abstracts Aluminium Industry Abstracts Technology Research Database Solid State and Superconductivity Abstracts Advanced Technologies Database with Aerospace METADEX MEDLINE - Academic |
DatabaseTitleList | Materials Research Database Algology Mycology and Protozoology Abstracts (Microbiology C) CrossRef PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Engineering Architecture |
EISSN | 2050-7518 |
EndPage | 5990 |
ExternalDocumentID | 10_1039_C5TB00625B 32262654 |
Genre | Journal Article |
GroupedDBID | -JG 0-7 0R~ 4.4 53G 705 AAEMU AAIWI AAJAE AANOJ AAWGC AAXHV ABASK ABDVN ABEMK ABJNI ABPDG ABRYZ ABXOH ACGFS ACIWK ACLDK ACPRK ADMRA ADSRN AEFDR AENEX AENGV AESAV AETIL AFLYV AFOGI AFRAH AFRDS AFVBQ AGEGJ AGRSR AGSTE AHGCF ALMA_UNASSIGNED_HOLDINGS ANBJS ANUXI APEMP ASKNT AUDPV AUNWK BLAPV BSQNT C6K D0L EBS ECGLT EE0 EF- EJD GGIMP GNO H13 HZ~ H~N J3G J3H J3I NPM O-G O9- R7C RAOCF RCNCU RNS ROL RPMJG RRC RSCEA SKA SKF SLH UCJ AAYXX CITATION M7N 7QF 7SR 7U5 8BQ 8FD JG9 L7M 7X8 |
ID | FETCH-LOGICAL-c353t-15c72f8ad2039d7be45e04fb5ddcceab3474a026a534429999dd8604d8b501983 |
ISSN | 2050-750X |
IngestDate | Fri Aug 16 03:46:41 EDT 2024 Fri Aug 16 04:44:29 EDT 2024 Thu Jul 25 08:45:16 EDT 2024 Fri Aug 23 03:18:01 EDT 2024 Sat Sep 28 08:30:50 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 29 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c353t-15c72f8ad2039d7be45e04fb5ddcceab3474a026a534429999dd8604d8b501983 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 32262654 |
PQID | 1705066152 |
PQPubID | 23462 |
PageCount | 13 |
ParticipantIDs | proquest_miscellaneous_2387654456 proquest_miscellaneous_1730064134 proquest_miscellaneous_1705066152 crossref_primary_10_1039_C5TB00625B pubmed_primary_32262654 |
PublicationCentury | 2000 |
PublicationDate | 2015-08-07 |
PublicationDateYYYYMMDD | 2015-08-07 |
PublicationDate_xml | – month: 08 year: 2015 text: 2015-08-07 day: 07 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Journal of materials chemistry. B, Materials for biology and medicine |
PublicationTitleAlternate | J Mater Chem B |
PublicationYear | 2015 |
References | Zhu (C5TB00625B-(cit31)/*[position()=1]) 2004; 108 Doss (C5TB00625B-(cit30)/*[position()=1]) 1993; 48 Liu (C5TB00625B-(cit34)/*[position()=1]) 2014; 2 Gratieri (C5TB00625B-(cit23)/*[position()=1]) 2011; 79 Chawla (C5TB00625B-(cit12)/*[position()=1]) 2011; 12 Yoldas (C5TB00625B-(cit27)/*[position()=1]) 1975; 10 Narasimha (C5TB00625B-(cit8)/*[position()=1]) 2014; 6 Samanta (C5TB00625B-(cit17)/*[position()=1]) 2010; 20 Lemmers (C5TB00625B-(cit19)/*[position()=1]) 2012; 28 Mohamed (C5TB00625B-(cit41)/*[position()=1]) 2011; 46 Beck (C5TB00625B-(cit2)/*[position()=1]) 2003; 125 Nanda (C5TB00625B-(cit4)/*[position()=1]) 2013; 9 Liu (C5TB00625B-(cit6)/*[position()=1]) 2012; 24 Ma (C5TB00625B-(cit21)/*[position()=1]) 2012; 50 Wu (C5TB00625B-(cit39)/*[position()=1]) 2009; 1 Weiss (C5TB00625B-(cit1)/*[position()=1]) 2014; 136 Pek (C5TB00625B-(cit18)/*[position()=1]) 2008; 3 Pryce (C5TB00625B-(cit35)/*[position()=1]) 2004; 14 Chiche (C5TB00625B-(cit32)/*[position()=1]) 2009; 11 Oshaben (C5TB00625B-(cit5)/*[position()=1]) 2014; 15 Raeburn (C5TB00625B-(cit3)/*[position()=1]) 2013; 42 Longo (C5TB00625B-(cit15)/*[position()=1]) 2012; 8 Paul (C5TB00625B-(cit20)/*[position()=1]) 2014; 8 Linsha (C5TB00625B-(cit22)/*[position()=1]) 2015; 259 Nirmala (C5TB00625B-(cit26)/*[position()=1]) 2013; 60 Ruan (C5TB00625B-(cit33)/*[position()=1]) 2001; 32 Hamilton (C5TB00625B-(cit37)/*[position()=1]) 2011; 133 Jin (C5TB00625B-(cit16)/*[position()=1]) 2011; 47 Priya (C5TB00625B-(cit36)/*[position()=1]) 1997; 16 Cyr (C5TB00625B-(cit25)/*[position()=1]) 1996; 14 Santoro (C5TB00625B-(cit38)/*[position()=1]) 2011; 115 Wang (C5TB00625B-(cit9)/*[position()=1]) 2009; 25 Zhang (C5TB00625B-(cit14)/*[position()=1]) 2014; 4 Cesar Cuggino (C5TB00625B-(cit40)/*[position()=1]) 2014; 11 Weng (C5TB00625B-(cit13)/*[position()=1]) 2006; 128 Llusar (C5TB00625B-(cit10)/*[position()=1]) 2008; 20 Nagahama (C5TB00625B-(cit11)/*[position()=1]) 2008; 18 Yu (C5TB00625B-(cit7)/*[position()=1]) 2012; 8 Amin (C5TB00625B-(cit24)/*[position()=1]) 2009; 3 Smith (C5TB00625B-(cit28)/*[position()=1]) 2008; 24 Han (C5TB00625B-(cit29)/*[position()=1]) 2014; 2 |
References_xml | – volume: 3 start-page: 671 year: 2008 ident: C5TB00625B-(cit18)/*[position()=1] publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2008.270 contributor: fullname: Pek – volume: 48 start-page: 15626 year: 1993 ident: C5TB00625B-(cit30)/*[position()=1] publication-title: Phys. Rev. B: Condens. Matter doi: 10.1103/PhysRevB.48.15626 contributor: fullname: Doss – volume: 6 start-page: 19385 year: 2014 ident: C5TB00625B-(cit8)/*[position()=1] publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/am505479z contributor: fullname: Narasimha – volume: 18 start-page: 1220 year: 2008 ident: C5TB00625B-(cit11)/*[position()=1] publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.200700587 contributor: fullname: Nagahama – volume: 24 start-page: 12405 year: 2008 ident: C5TB00625B-(cit28)/*[position()=1] publication-title: Langmuir doi: 10.1021/la802234x contributor: fullname: Smith – volume: 2 start-page: 296 year: 2014 ident: C5TB00625B-(cit29)/*[position()=1] publication-title: ACS Sustainable Chem. Eng. doi: 10.1021/sc400352a contributor: fullname: Han – volume: 8 start-page: 8050 year: 2014 ident: C5TB00625B-(cit20)/*[position()=1] publication-title: ACS Nano doi: 10.1021/nn5020787 contributor: fullname: Paul – volume: 60 start-page: 417 year: 2013 ident: C5TB00625B-(cit26)/*[position()=1] publication-title: Biotechnol. Appl. Biochem. doi: 10.1002/bab.1116 contributor: fullname: Nirmala – volume: 47 start-page: 997 year: 2011 ident: C5TB00625B-(cit16)/*[position()=1] publication-title: Chem. Commun. doi: 10.1039/C0CC04285D contributor: fullname: Jin – volume: 115 start-page: 2503 year: 2011 ident: C5TB00625B-(cit38)/*[position()=1] publication-title: J. Phys. Chem. B doi: 10.1021/jp1111394 contributor: fullname: Santoro – volume: 16 start-page: 1584 year: 1997 ident: C5TB00625B-(cit36)/*[position()=1] publication-title: J. Mater. Sci. Lett. doi: 10.1023/A:1018568418302 contributor: fullname: Priya – volume: 1 start-page: 319 year: 2009 ident: C5TB00625B-(cit39)/*[position()=1] publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/am8000456 contributor: fullname: Wu – volume: 14 start-page: 2303 year: 2004 ident: C5TB00625B-(cit35)/*[position()=1] publication-title: J. Mater. Chem. doi: 10.1039/b400922c contributor: fullname: Pryce – volume: 4 start-page: 4593 year: 2014 ident: C5TB00625B-(cit14)/*[position()=1] publication-title: Sci. Rep. doi: 10.1038/srep04593 contributor: fullname: Zhang – volume: 46 start-page: 460 year: 2011 ident: C5TB00625B-(cit41)/*[position()=1] publication-title: Acta Pharmacol. Sin. contributor: fullname: Mohamed – volume: 125 start-page: 13922 year: 2003 ident: C5TB00625B-(cit2)/*[position()=1] publication-title: J. Am. Chem. Soc. doi: 10.1021/ja038521k contributor: fullname: Beck – volume: 24 start-page: 3751 year: 2012 ident: C5TB00625B-(cit6)/*[position()=1] publication-title: Chem. Mater. doi: 10.1021/cm302318b contributor: fullname: Liu – volume: 14 start-page: 247 year: 1996 ident: C5TB00625B-(cit25)/*[position()=1] publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/0731-7085(95)01598-1 contributor: fullname: Cyr – volume: 9 start-page: 4198 year: 2013 ident: C5TB00625B-(cit4)/*[position()=1] publication-title: Soft Matter doi: 10.1039/c3sm27050e contributor: fullname: Nanda – volume: 10 start-page: 1856 year: 1975 ident: C5TB00625B-(cit27)/*[position()=1] publication-title: J. Mater. Sci. doi: 10.1007/BF00754473 contributor: fullname: Yoldas – volume: 136 start-page: 7519 year: 2014 ident: C5TB00625B-(cit1)/*[position()=1] publication-title: J. Am. Chem. Soc. doi: 10.1021/ja503363v contributor: fullname: Weiss – volume: 28 start-page: 12311 year: 2012 ident: C5TB00625B-(cit19)/*[position()=1] publication-title: Langmuir doi: 10.1021/la301917e contributor: fullname: Lemmers – volume: 108 start-page: 4245 year: 2004 ident: C5TB00625B-(cit31)/*[position()=1] publication-title: J. Phys. Chem. B doi: 10.1021/jp049485u contributor: fullname: Zhu – volume: 25 start-page: 13194 year: 2009 ident: C5TB00625B-(cit9)/*[position()=1] publication-title: Langmuir doi: 10.1021/la901869t contributor: fullname: Wang – volume: 20 start-page: 6881 year: 2010 ident: C5TB00625B-(cit17)/*[position()=1] publication-title: J. Mater. Chem. doi: 10.1039/c0jm00491j contributor: fullname: Samanta – volume: 3 start-page: 257 year: 2009 ident: C5TB00625B-(cit24)/*[position()=1] publication-title: Eur. J. Dent. doi: 10.1055/s-0039-1697442 contributor: fullname: Amin – volume: 11 start-page: 11310 year: 2009 ident: C5TB00625B-(cit32)/*[position()=1] publication-title: Phys. Chem. Chem. Phys. doi: 10.1039/b914062j contributor: fullname: Chiche – volume: 133 start-page: 3365 year: 2011 ident: C5TB00625B-(cit37)/*[position()=1] publication-title: J. Am. Chem. Soc. doi: 10.1021/ja106095w contributor: fullname: Hamilton – volume: 79 start-page: 320 year: 2011 ident: C5TB00625B-(cit23)/*[position()=1] publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2011.05.006 contributor: fullname: Gratieri – volume: 42 start-page: 5143 year: 2013 ident: C5TB00625B-(cit3)/*[position()=1] publication-title: Chem. Soc. Rev. doi: 10.1039/c3cs60030k contributor: fullname: Raeburn – volume: 32 start-page: 745 year: 2001 ident: C5TB00625B-(cit33)/*[position()=1] publication-title: J. Raman Spectrosc. doi: 10.1002/jrs.736 contributor: fullname: Ruan – volume: 15 start-page: 1436 year: 2014 ident: C5TB00625B-(cit5)/*[position()=1] publication-title: Biomacromolecules doi: 10.1021/bm5000423 contributor: fullname: Oshaben – volume: 2 start-page: 5267 year: 2014 ident: C5TB00625B-(cit34)/*[position()=1] publication-title: J. Mater. Chem. A doi: 10.1039/c3ta14665k contributor: fullname: Liu – volume: 8 start-page: 3329 year: 2012 ident: C5TB00625B-(cit7)/*[position()=1] publication-title: Soft Matter doi: 10.1039/c2sm07309a contributor: fullname: Yu – volume: 8 start-page: 1344 year: 2012 ident: C5TB00625B-(cit15)/*[position()=1] publication-title: Soft Matter doi: 10.1039/C1SM06708G contributor: fullname: Longo – volume: 50 start-page: 3001 year: 2012 ident: C5TB00625B-(cit21)/*[position()=1] publication-title: Carbon doi: 10.1016/j.carbon.2012.02.083 contributor: fullname: Ma – volume: 11 start-page: 2239 year: 2014 ident: C5TB00625B-(cit40)/*[position()=1] publication-title: Mol. Pharmaceutics doi: 10.1021/mp400615n contributor: fullname: Cesar Cuggino – volume: 128 start-page: 11663 year: 2006 ident: C5TB00625B-(cit13)/*[position()=1] publication-title: J. Am. Chem. Soc. doi: 10.1021/ja063408q contributor: fullname: Weng – volume: 20 start-page: 782 year: 2008 ident: C5TB00625B-(cit10)/*[position()=1] publication-title: Chem. Mater. doi: 10.1021/cm702141e contributor: fullname: Llusar – volume: 12 start-page: 560 year: 2011 ident: C5TB00625B-(cit12)/*[position()=1] publication-title: Biomacromolecules doi: 10.1021/bm100980w contributor: fullname: Chawla – volume: 259 start-page: 313 year: 2015 ident: C5TB00625B-(cit22)/*[position()=1] publication-title: Chem. Eng. J. doi: 10.1016/j.cej.2014.07.137 contributor: fullname: Linsha |
SSID | ssj0000816834 |
Score | 2.1329234 |
Snippet | The supramolecular assembly of stimuli-responsive gels is renowned in organic, polymeric and biological systems, but it is seldom reported in inorganic gel... |
SourceID | proquest crossref pubmed |
SourceType | Aggregation Database Index Database |
StartPage | 5978 |
SubjectTerms | Architecture Assembly Cages Candida Candida albicans Drug delivery systems Drugs Three dimensional Trichophyton rubrum Two dimensional |
Title | Supramolecular association of 2D alumino-siloxane aquagel building blocks to 3D porous cages and its efficacy for topical and injectable delivery of fluconazole, an antifungal drug |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32262654 https://search.proquest.com/docview/1705066152 https://search.proquest.com/docview/1730064134 https://search.proquest.com/docview/2387654456 |
Volume | 3 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLa27gUeEPeVm4zGW0hJYzuXx3UdGgjx0g7trbKdZKsoSelSCfq7-IGcY-e2jqHBS1Tl4qQ-n30-25_PIeSNUioOsyRwfZ5xlytoc3HgJ24UpSqGEVektVH5fg5OTvnHM3G2s3vQUS2tSzXQmz_uK_kfq8I5sCvukv0HyzaFwgn4DfaFI1gYjrey8WS9XMlvdYJbR7ZVjRzQHzsSup55XriX80XxQwKflN9xcnLhqCobNgrX9VcT5YFhxoYVKmK1xMAP9apCikEmMCm8ESQWyya8wDzHOZxq69UC9R1mtT5DEXwuN4UVKktUO5dz8J_nuB60Wp_fwIeBOts6c3SdhG7gjOx-ovqK0ZZ2wkZtKwO-yM2F_GlyGOBsw-VF43SMlNyZSDAShqi2u8ww83ReNhPiU7OndGHo9GSeY8Tn1ZXnTQcN3Wi6dEYDZzLoTpkMhRHshW3P6nvCc4EqnVkn2D1XOYPKNbBOC6gmZmw_D8OwqMMZRGxznl7zRx7DcK5HYjrCzaqiXZVqlAZbzriRSBpxAItn7bO7ZM8PYxH2yN7h8fTDp2Yq0eROMfqJ5o_VgXhZ_K4t4Cr1umE8ZXjV9D65VwGAHlp0PyA7af6Q3O2EyXxEfl3FOe3gnBYZ9cd0G-e0wjmtcU4tzmlZUDamFufU4JwCjijgnNY4pwAyWuHcXmxwTmuc42s7OH8L99EW5RRR_picvj-eHp24VbYRVzPBSncodOhnkUx8qLUkVCkXqcczJZJE61QqxkMuPT-QgnEkcXGcJFHg8SRSAsZJEXtCenmRp_uERhHP4giouQLyC8XGXGrP1zEXnoSydZ8c1IaYLW1Qmdl1e_fJ69pGM2h1uJAHFQjVM8MQWDBUAOr9t3sYDjeGjN98D9D1MMBoXEGfPLUgaL4HHH3gw8Vnt_rW5-RO29BekF65Wqcvga2X6lWF1t-Dg_KZ |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Royal Society of Chemistry |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Supramolecular+association+of+2D+alumino-siloxane+aquagel+building+blocks+to+3D+porous+cages+and+its+efficacy+for+topical+and+injectable+delivery+of+fluconazole%2C+an+antifungal+drug&rft.jtitle=Journal+of+materials+chemistry.+B%2C+Materials+for+biology+and+medicine&rft.au=Vazhayal%2C+Linsha&rft.au=Kumar+Sasidharan%2C+Nishanth&rft.au=Talasila%2C+Sindhoor&rft.au=Kumar%2C+Dileep+B.+S.&rft.date=2015-08-07&rft.issn=2050-750X&rft.eissn=2050-7518&rft.volume=3&rft.issue=29&rft.spage=5978&rft.epage=5990&rft_id=info:doi/10.1039%2FC5TB00625B&rft.externalDBID=n%2Fa&rft.externalDocID=10_1039_C5TB00625B |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2050-750X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2050-750X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2050-750X&client=summon |