Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development

• Published in: Development (Cambridge) Vol. 144; no. 18; pp. 3264 - 3277
• Main Authors: Sankar, Aditya, Kooistra, Susanne Marije, Gonzalez, Javier Martin, Ohlsson, Claes, Poutanen, Matti, Helin, Kristian
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 15.09.2017
• Subjects: acute myeloid-leukemia; Animals; Blastocysts; Chromatin; colony-stimulating factors; Cytokines - metabolism; Developmental Biology; Embryo Implantation - genetics; Embryo, Mammalian - metabolism; Embryogenesis; Epigenetics; factor-deficient mice; Female; Female fertility; Fertility; Fertilization; Gene Expression Regulation, Developmental; Gene regulation; gene-expression; Genitalia, Female - metabolism; Histone demethylase; Histone Demethylases - metabolism; Histone H3; Histones; human breast-cancer; in-vitro; Infertility, Female - genetics; Infertility, Female - pathology; jmjd2 family; luteinizing-hormone; Lysine; Maternal effect; Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy); Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci); Mice, Inbred C57BL; Mice, Knockout; null mutation; Oocytes; Post-translation; Pre-implantation development; Pregnancy; Signal Transduction; targeted disruption; Transcription; Uterus; Uterus - metabolism; Zygote - metabolism; Epigenetics; Histone demethylase; Maternal effect; Transcription; Pre-implantation development; Female fertility

Regulation of chromatin composition through post-translational modifications of histones contributes to transcriptional regulation and is essential for many cellular processes, including differentiation and development. KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-meth...