Connective tissue growth factor stimulates osteosarcoma cell migration and induces osteosarcoma metastasis by upregulating VCAM-1 expression

• Published in: Biochemical pharmacology Vol. 155; pp. 71 - 81
• Main Authors: Hou, Chun-Han, Yang, Rong-sen, Tsao, Ya-Ting
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.09.2018
• Subjects: Cell migration; CTGF; Osteosarcoma metastasis; VCAM-1; Osteosarcoma metastasis; VCAM-1; Cell migration; CTGF

[Display omitted] Osteosarcoma is the most common bone malignancy that occurs in the young population. After osteosarcoma cells metastasize to the lung, prognosis is very poor owing to difficulties in early diagnosis and effective treatment. Recently, connective tissue growth factor (CTGF) was repor...