CDC6 regulates both G2/M transition and metaphase‐to‐anaphase transition during the first meiosis of mouse oocytes

• Published in: Journal of cellular physiology Vol. 235; no. 7-8; pp. 5541 - 5554
• Main Authors: Yi, Zi‐Yun, Meng, Tie‐Gang, Ma, Xue‐Shan, Li, Jian, Zhang, Chun‐Hui, Ouyang, Ying‐Chun, Schatten, Heide, Qiao, Jie, Sun, Qing‐Yuan, Qian, Wei‐Ping
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2020
• Subjects: Anaphase; Anaphase - genetics; Animals; Assembly; Cdc2 protein; CDC6; Cell culture; Cell Cycle Proteins - genetics; Cell division; Centrosome; Chromosomes; Cycle protein; Cyclin B1; Deoxyribonucleic acid; Depletion; DNA; DNA biosynthesis; E-cadherin; Extrusion; Female; G2 Phase Cell Cycle Checkpoints - genetics; Gametocytes; germinal vesicle breakdown; Localization; M Phase Cell Cycle Checkpoints - genetics; Meiosis; Meiosis - genetics; Metaphase; Metaphase - genetics; Mice; Nuclear Proteins - genetics; oocyte; Oocytes; Oocytes - growth & development; Oocytes - metabolism; Phenotypes; Phosphorylation; Replication initiation; spindle; Spindle Apparatus - genetics; Spindles; Tubulin; meiosis; oocyte; CDC6; spindle; germinal vesicle breakdown

Cell division cycle protein, CDC6, is essential for the initiation of DNA replication. CDC6 was recently shown to inhibit the microtubule‐organizing activity of the centrosome. Here, we show that CDC6 is localized to the spindle from pro‐metaphase I (MI) to MII stages of oocytes, and it plays import...