RGS10 Deficiency Alleviated Intestinal Mucosal Inflammation Through Suppression of Th1/Th17 Cell Immune Responses in Ulcerative Colitis

• Published in: Immunology Vol. 174; no. 1; pp. 139 - 152
• Main Authors: Yang, Yonghong, Shao, Yiming, Gao, Xizhuang, Hu, Zongjing, Wang, Yan, Ma, Cuimei, Jin, Guiyuan, Zhu, Fengqin, Dong, Guanjun, Zhou, Guangxi
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2025
• Subjects: Animals; CD4 antigen; Cell differentiation; Colitis, Ulcerative - immunology; Colitis, Ulcerative - metabolism; Cytokines - metabolism; Dextran; Dextran Sulfate; Dextrans; Disease Models, Animal; Female; Flow cytometry; Gene expression; Gene sequencing; Helper cells; Humans; Immune response (cell-mediated); Immune system; Immunohistochemistry; Immunoprecipitation; Inflammation; Inflammation - immunology; Inflammation - metabolism; Inflammatory bowel disease; Inflammatory bowel diseases; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Intestine; Lamina propria; Leukocytes (mononuclear); Lymph nodes; Lymphocytes; Lymphocytes T; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucosal immunity; Peripheral blood mononuclear cells; Phosphorylation; Polymerase chain reaction; Protein deficiency; Protein-tyrosine-phosphatase; Proteins; PTPN2; PTPN2 protein; RGS Proteins - deficiency; RGS Proteins - genetics; RGS Proteins - metabolism; RGS10; Signal Transduction; Th1 cells; Th1 Cells - immunology; Th17 cells; Th17 Cells - immunology; Th17 Cells - metabolism; Tyrosine; Ulcerative colitis; Western blotting; RGS10; ulcerative colitis; Th1 cells; PTPN2; Th17 cells

ABSTRACT Regulator of G‐protein signalling (RGS) 10 plays critical roles in several immune related diseases. However, whether RGS10 is involved in colonic inflammation of ulcerative colitis (UC) is still obscure. This study aimed to investigate the role of RGS10 in UC. In this study, RGS10 expressio...