Comprehensive Profiling of the Rheumatoid Arthritis Antibody Repertoire

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 72; no. 2; pp. 242 - 250
• Main Authors: Lo, Ken C., Sullivan, Eric, Bannen, Ryan M., Jin, Huiyan, Rowe, Mark, Li, Hanying, Pinapati, Richard S., Cartwright, Adam J., Tan, John C., Patel, Jigar, Keystone, Edward C., Siminovitch, Katherine A.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2020
• Subjects: Anti-Citrullinated Protein Antibodies - blood; Antibodies; Arginine; Arrays; Arthritis; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - immunology; Assaying; Autoantibodies; Autoantibodies - blood; Biomarkers; Citrulline; Cohort Studies; Control equipment; Density; Diagnostic systems; Epitopes; Epitopes - blood; Humans; Lysine; Peptides; Proteins; Proteomes; Rheumatoid arthritis; Sensitivity

Objective Autoantibodies against citrullinated proteins are found in 64–89% of rheumatoid arthritis (RA) patients, with 88–99% specificity. This study was undertaken to create an unbiased, comprehensive profile of serum antibodies against the human proteome, including the citrullinome and the homoci...