Strategies for nonviral nanoparticle-based delivery of CRISPR/Cas9 therapeutics

• Published in: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Vol. 12; no. 3; p. e1609
• Main Authors: Chen, Fengqian, Alphonse, Martin, Liu, Qi
• Format: Journal Article
• Language: English
• Published: United States 01.05.2020
• Subjects: CRISPR-Cas; genome editing; nanomedicine; drug delivery
• ISSN: 1939-0041
• DOI: 10.1002/wnan.1609

CRISPR-based genome editing technology has become an important potential therapeutic tool for various diseases. A vital challenge is to reach a safe, efficient, and clinically suitable delivery of a CRISPR-associated protein and a single-guide RNA. A possible translational approach to applying CRISP...