Preparation and characterization of enalapril maleate-loaded nanoparticles using amphiphilic diblock copolymers

• Published in: Journal of applied polymer science Vol. 74; no. 12; pp. 2856 - 2867
• Main Authors: Yoo, Youngtai, Kim, Dong-Chul, Kim, Tae-Yoon
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 13.12.1999
• Subjects: block copolymer; enalapril maleate; micelles; nanoparticles; parenteral delivery; poly(ethylene oxide)-b-polycaprolactone

Nanoparticles with the dimensions of circa 50 nm prepared from the micellar aggregation of diblock copolymers of poly(ethylene oxide) and polycaprolactone (PEO–b–PCL) were explored as a parenteral carrier system for water‐soluble organic drugs in salt form. Enalapril maleate (EPM), developed for hyp...