Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/β‐catenin signaling

• Published in: Journal of cellular biochemistry Vol. 120; no. 10; pp. 17273 - 17282
• Main Authors: Lv, Min‐yi, Shi, Chuan‐jian, Pan, Fei‐fei, Shao, Jiang, Feng, Lu, Chen, Guoqin, Ou, Caiwen, Zhang, Jin‐fang, Fu, Wei‐ming
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2019
• Subjects: Antineoplastic drugs; Antitumor agents; Apoptosis; Breast; Cardiovascular diseases; Catenin; Cell cycle; Cell proliferation; Cell viability; Colon; Cytoplasm; Deactivation; Drug delivery; Drug development; Hepatocellular carcinoma; Inactivation; Intestinal microflora; Liver cancer; Metabolites; Microbiota; Prostate; Signaling; Translocation; Tumors; urolithin B; Wnt protein; Wnt/β‐catenin; Xenografts; Xenotransplantation; apoptosis; urolithin B; cell cycle; Wnt/β-catenin; hepatocellular carcinoma

Consumption of dietary ellagitannins (ETs) has been proven to benefit multiple chronic health disorders including cancers and cardiovascular diseases. Urolithins, gut microbiota metabolites derived from ETs, are considered as the molecules responsible for these health effects. Previous studies have...