NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

• Published in: Journal of cellular physiology Vol. 237; no. 7; pp. 2770 - 2795
• Main Authors: Mirzaei, Sepideh, Saghari, Sam, Bassiri, Farzaneh, Raesi, Rasoul, Zarrabi, Ali, Hushmandi, Kiavash, Sethi, Gautam, Tergaonkar, Vinay
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2022
• Subjects: Breast; Cancer; cancer therapy; chemoresistance; Chemotherapy; Drug resistance; EMT; Gastric cancer; Growth factors; Invasiveness; Medical prognosis; Mesenchyme; Metastases; Metastasis; NF‐κB signaling; Nuclear transport; Translocation; Tumor cells; Tumors; Vimentin; NF-κB signaling; cancer therapy; chemoresistance; metastasis; EMT

Metastasis of tumor cells is a complex challenge and significantly diminishes the overall survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) is a well‐known mechanism responsible for the invasiveness of tumor cells. A number of molecular pathways can regulate t...