Melanocortin 4 receptor–mediated effects of amylin on thermogenesis and regulation of food intake

• Published in: Diabetes/metabolism research and reviews Vol. 35; no. 5; pp. e3149 - n/a
• Main Authors: Li, Xiaojing, Fan, Kuikui, Li, Qiang, Pan, Deng, Hai, Rihan, Du, Chenguang
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2019
• Subjects: Acetyl-CoA Carboxylase - genetics; Acetyl-CoA Carboxylase - metabolism; Adipose tissue (brown); Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - metabolism; Amylin; Animals; Appetite Regulation - drug effects; Appetite Regulation - genetics; Arcuate nucleus; Body weight loss; brown adipose tissue; Eating - drug effects; Eating - genetics; Energy balance; Feeding; Food; Food consumption; Food intake; Homeostasis; Hypothalamus; Insulin; Islet Amyloid Polypeptide - pharmacology; Male; Melanocortin; melanocortin 4 receptor; Melanocortin MC4 receptors; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreas; Phosphorylation; Receptor, Melanocortin, Type 4 - genetics; Receptor, Melanocortin, Type 4 - physiology; Signal transduction; Signal Transduction - drug effects; Signal Transduction - genetics; Thermogenesis; Thermogenesis - drug effects; Thermogenesis - genetics; Uncoupling Protein 1 - genetics; Uncoupling Protein 1 - metabolism; melanocortin 4 receptor; thermogenesis; amylin; brown adipose tissue; hypothalamus; food intake

Aims Amylin, a pancreatic hormone cosecreted with insulin, exerts important anorexic and weight‐loss effects. Melanocortin 4 receptor (MC4R) signalling plays a critical role in energy homeostasis; however, its role on amylin‐dependent regulation of food intake and adaptive thermogenesis of interscap...