BRAF V600E mutation mediates invasive and growth features in ameloblastoma

• Published in: Oral diseases Vol. 30; no. 7; pp. 4426 - 4439
• Main Authors: Zhang, Chen‐Xi, Zhang, Lin‐Zhou, Lin, Hao, Man, Qi‐Wen, Liu, Bing
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.10.2024
• Subjects: Adolescent; Adult; Aged; Ameloblastoma; Ameloblastoma - genetics; Ameloblastoma - metabolism; Ameloblastoma - pathology; BRAF protein; Comparative analysis; Correlation analysis; Extracellular signal-regulated kinase; Female; Gelatinase A; Gelatinase B; Humans; Immunofluorescence; Immunohistochemistry; Jaw; Jaw Neoplasms - genetics; Jaw Neoplasms - metabolism; Jaw Neoplasms - pathology; Ki-67 Antigen - metabolism; Kinases; Ki‐67 antigen; Male; MAP kinase; MAP kinase signaling system; MAP Kinase Signaling System - genetics; Mass spectroscopy; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Middle Aged; Mouth Mucosa - metabolism; Mouth Mucosa - pathology; Mutation; neoplasm invasiveness; Neoplasm Invasiveness - genetics; Odontogenic Cysts - genetics; Odontogenic Cysts - metabolism; Odontogenic Cysts - pathology; Phosphorylation; Proteomics; Proto-Oncogene Proteins B-raf - genetics; Signal transduction; Young Adult; BRAF protein; MAP kinase signaling system; neoplasm invasiveness; Ki‐67 antigen; ameloblastoma

Objectives Ameloblastoma (AM), a locally aggressive tumor with extensive growth capacity, causes significant damage to the jaw and affects facial appearance. Although the high prevalence of BRAF V600E mutation in AM is known, its specific impacts on patients with AM remain unclear. Thus, the present...