Poorly differentiated histologic grade correlates with worse survival in SMAD4 negative pancreatic adenocarcinoma patients

• Published in: Journal of surgical oncology Vol. 123; no. 2; pp. 389 - 398
• Main Authors: Park, Joon Y., King, Jonathan, Reber, Howard, Joe Hines, Oscar, Mederos, Michael A., Wang, Hanlin L., Dawson, David, Wainberg, Zev, Donahue, Timothy, Girgis, Mark
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2021
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - metabolism; Cancer surgery; carcinoma; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - mortality; Carcinoma, Pancreatic Ductal - pathology; Carcinoma, Pancreatic Ductal - surgery; Cohort analysis; cohort studies; Female; Follow-Up Studies; Humans; Male; Medical prognosis; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local - metabolism; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Pancreatic cancer; pancreatic ductal; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - surgery; Prospective Studies; Retrospective Studies; SMAD4 protein; Smad4 Protein - metabolism; Surgical outcomes; Survival analysis; Survival Rate; transcription factors; cohort studies; SMAD4 protein; carcinoma; pancreatic ductal; transcription factors

Background and Objectives This study investigated the influence of the transcription factor SMAD4 on overall patient survival following surgical resection of pancreatic ductal adenocarcinoma (PDAC). Methods The SMAD4 status of 125 surgically resected PDAC specimens at a large academic center from 20...