Nanoparticles as new tools for inhibition of cancer angiogenesis

• Published in: Journal of cellular physiology Vol. 233; no. 4; pp. 2902 - 2910
• Main Authors: Hashemi Goradel, Nasser, Ghiyami‐Hour, Farshid, Jahangiri, Samira, Negahdari, Babak, Sahebkar, Amirhossein, Masoudifar, Aria, Mirzaei, Hamed
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2018
• Subjects: Angiogenesis; Angiogenesis Inhibitors - therapeutic use; Animals; Cancer; Cascades; Chemical compounds; Endothelium; Humans; Hydrogels; In vivo methods and tests; Nanoparticles; Nanoparticles - therapeutic use; Nanotechnology; Neoplasms - blood supply; Neoplasms - pathology; Neovascularization, Pathologic - therapy; Nutrients; Oxygen; Pharmacology; Protein-tyrosine kinase; Receptors; Receptors, Vascular Endothelial Growth Factor - metabolism; Survival; TKRs; Tumor cells; Tumors; Tyrosine; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; VEGF; nanoparticles; VEGF; angiogenesis; TKRs

Angiogenesis is known as one of the hallmarks of cancer. Multiple lines evidence indicated that vascular endothelium growth factor (VEGF) is a key player in the progression of angiogenesis and exerts its functions via interaction with tyrosine kinase receptors (TKRs). These receptors could trigger a...