DNA primase polypeptide 1 (PRIM1) involves in estrogen‐induced breast cancer formation through activation of the G2/M cell cycle checkpoint

• Published in: International journal of cancer Vol. 144; no. 3; pp. 615 - 630
• Main Authors: Lee, Wei‐Hwa, Chen, Li‐Ching, Lee, Chia‐Jung, Huang, Chi‐Cheng, Ho, Yuan‐Soon, Yang, Po‐Sheng, Ho, Chi‐Tang, Chang, Hang‐Lung, Lin, I‐Hsuan, Chang, Hui‐Wen, Liu, Yun‐Ru, Wu, Chih‐Hsiung, Tu, Shih‐Hsin
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2019; Wiley Subscription Services, Inc
• Subjects: Breast cancer; Cancer; cancer prevention; Cell cycle; Copy number; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA primase; DNA primase polypeptide 1; Estrogen receptors; Gene expression; inotilone; Medical research; Okazaki fragments; Polypeptides; Primase; Primers; siRNA; Therapeutic applications; Tumors; Xenografts; breast cancer; inotilone; cancer prevention; DNA primase polypeptide 1

The DNA primase polypeptide 1 (PRIM1) is responsible for synthesizing small RNA primers for Okazaki fragments generated during discontinuous DNA replication. PRIM1 mRNA expression levels in breast tumor samples were detected by real‐time PCR analysis. Xenografted tumor model was established to study...