Identifying hemophilia B carriers: Utility of aPTT, factor IX levels and ratios of factor IX to other Vitamin K dependent factors

• Published in: Haemophilia : the official journal of the World Federation of Hemophilia Vol. 30; no. 4; pp. 1003 - 1009
• Main Authors: Shu, Michael, Malcolmson, Caroline, Bosch, Alessandra, Markovic, Teodora, Wakefield, Cindy, Bouskill, Vanessa, Carcao, Manuel
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2024
• Subjects: activated partial thromboplastin time; Bleeding; blood coagulation factors; Coagulation factors; factor IX; Factor IX deficiency; genetic carrier screening; Hemophilia; hemophilia B; Ratios; Thromboplastin; Vitamin K; blood coagulation factors; factor IX; genetic carrier screening; activated partial thromboplastin time; hemophilia B

Introduction Diagnosing hemophilia B (HB) carrier status is important to manage bleeding in carriers and to prevent bleeding in potential offspring. Without a family history of hemophilia, diagnosing HB carrier status is challenging. Genetic testing is the gold‐standard, however it is reserved for i...