Meta‐analysis and trial sequential analysis of randomized controlled trials comparing aggressive versus non‐aggressive intravenous fluid therapy in acute pancreatitis: an insight into the existence of type 2 error

• Published in: Journal of gastroenterology and hepatology Vol. 39; no. 10; pp. 2018 - 2030
• Main Authors: Evans, Daisy, Hajibandeh, Shahin, Hajibandeh, Shahab, Athwal, Tejinderjit S, Satyadas, Thomas
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.10.2024
• Subjects: Acute Disease; Acute pancreatitis; Aggressive; Clinical trials; Fluid resuscitation; Fluid Therapy - methods; Humans; Inflammation; Intravenous administration; Intravenous fluid therapy; Intravenous therapy; Length of Stay; Morbidity; Mortality; Necrosis; Pancreas; Pancreatitis; Pancreatitis - mortality; Pancreatitis - therapy; Patients; Randomized Controlled Trials as Topic; Respiratory failure; Sepsis; Sepsis - mortality; Sepsis - therapy; Statistical analysis; Systemic inflammatory response syndrome; Systemic Inflammatory Response Syndrome - etiology; Systemic Inflammatory Response Syndrome - therapy; Treatment Outcome; Acute pancreatitis; Intravenous fluid therapy; Fluid resuscitation; Aggressive

Background and Aim We aimed to evaluate comparative outcomes of aggressive versus non‐aggressive intravenous fluid (IVF) therapy in patients with acute pancreatitis. Methods A systematic search of electronic data sources and bibliographic reference lists were conducted. All randomized controlled tri...