Exploring the potential of radiolabeled duramycin as an infection imaging probe

• Published in: Drug development research Vol. 85; no. 1; pp. e22138 - n/a
• Main Authors: Kumar, Anuj, Mitra, Jyotsna Bhatt, Khatoon, Elina, Pramanik, Aparna, Sharma, Rohit K., Chandak, Ashok, Rakshit, Sutapa, Mukherjee, Archana
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2024
• Subjects: 99mTc radiopharmaceuticals; 99mTc‐labeled duramycin; Antimicrobial peptides; Bacteria; Cancer therapies; Cardiotoxicity; Computed tomography; duramycin; Dye releases; Dyes; E coli; Imaging techniques; infection imaging; Infections; Medical imaging; Medical research; Membranes; Phosphatidylethanolamine; Photon emission; Radiochemistry; Radiolabelling; Single photon emission computed tomography; SPECT imaging; Tomography; Tracers; infection imaging; 99mTc-labeled duramycin; duramycin; 99mTc radiopharmaceuticals; SPECT imaging; E. coli; antimicrobial peptides

The continuous pursuit of designing an ideal infection imaging agent is a crucial and ongoing endeavor in the field of biomedical research. Duramycin, an antimicrobial peptide exerts its antimicrobial action on bacteria by specific recognition of phosphatidylethanolamine (PE) moiety present on most...