Biological models in multiple sclerosis

Considering the etiology of multiple sclerosis (MS) is still unknown, experimental models resembling specific aspects of this immune‐mediated demyelinating human disease have been developed to increase the understanding of processes related to pathogenesis, disease evolution, evaluation of therapeut...

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Published inJournal of neuroscience research Vol. 98; no. 3; pp. 491 - 508
Main Authors Sanabria‐Castro, Alfredo, Flores‐Díaz, Marietta, Alape‐Girón, Alberto
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.03.2020
Subjects
Animal diseases
Animal models
Biological models (mathematics)
Demyelination
disease animal models
Disease control
Etiology
Experimental allergic encephalomyelitis
experimental autoimmune encephalomyelitis
In vivo methods and tests
Multiple sclerosis
Myelination
Pathogenesis
Therapeutic applications
viral encephalomyelitis
disease animal models
experimental autoimmune encephalomyelitis
demyelination
viral encephalomyelitis
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Abstract Considering the etiology of multiple sclerosis (MS) is still unknown, experimental models resembling specific aspects of this immune‐mediated demyelinating human disease have been developed to increase the understanding of processes related to pathogenesis, disease evolution, evaluation of therapeutic interventions, and demyelination and remyelination mechanisms. Based on the nature of the investigation, biological models may include in vitro, in vivo, and ex vivo assessments. Even though these approaches have disclosed valuable information, every disease animal model has limitations and can only replicate specific features of MS. In vitro and ex vivo models generally do not reflect what occurs in the organism, and in vivo animal models are more likely used; nevertheless, they are able to reproduce only certain stages of the disease. In vivo MS disease animal models in mammals include: experimental autoimmune encephalomyelitis, viral encephalomyelitis, and induced demyelination. This review examines and describes the most common biological disease animal models for the study of MS, their specific characteristics and limitations.
AbstractList Considering the etiology of multiple sclerosis (MS) is still unknown, experimental models resembling specific aspects of this immune‐mediated demyelinating human disease have been developed to increase the understanding of processes related to pathogenesis, disease evolution, evaluation of therapeutic interventions, and demyelination and remyelination mechanisms. Based on the nature of the investigation, biological models may include in vitro , in vivo , and ex vivo assessments. Even though these approaches have disclosed valuable information, every disease animal model has limitations and can only replicate specific features of MS. In vitro and ex vivo models generally do not reflect what occurs in the organism, and in vivo animal models are more likely used; nevertheless, they are able to reproduce only certain stages of the disease. In vivo MS disease animal models in mammals include: experimental autoimmune encephalomyelitis, viral encephalomyelitis, and induced demyelination. This review examines and describes the most common biological disease animal models for the study of MS, their specific characteristics and limitations.
Considering the etiology of multiple sclerosis (MS) is still unknown, experimental models resembling specific aspects of this immune‐mediated demyelinating human disease have been developed to increase the understanding of processes related to pathogenesis, disease evolution, evaluation of therapeutic interventions, and demyelination and remyelination mechanisms. Based on the nature of the investigation, biological models may include in vitro, in vivo, and ex vivo assessments. Even though these approaches have disclosed valuable information, every disease animal model has limitations and can only replicate specific features of MS. In vitro and ex vivo models generally do not reflect what occurs in the organism, and in vivo animal models are more likely used; nevertheless, they are able to reproduce only certain stages of the disease. In vivo MS disease animal models in mammals include: experimental autoimmune encephalomyelitis, viral encephalomyelitis, and induced demyelination. This review examines and describes the most common biological disease animal models for the study of MS, their specific characteristics and limitations.
Considering the etiology of multiple sclerosis (MS) is still unknown, experimental models resembling specific aspects of this immune-mediated demyelinating human disease have been developed to increase the understanding of processes related to pathogenesis, disease evolution, evaluation of therapeutic interventions, and demyelination and remyelination mechanisms. Based on the nature of the investigation, biological models may include in vitro, in vivo, and ex vivo assessments. Even though these approaches have disclosed valuable information, every disease animal model has limitations and can only replicate specific features of MS. In vitro and ex vivo models generally do not reflect what occurs in the organism, and in vivo animal models are more likely used; nevertheless, they are able to reproduce only certain stages of the disease. In vivo MS disease animal models in mammals include: experimental autoimmune encephalomyelitis, viral encephalomyelitis, and induced demyelination. This review examines and describes the most common biological disease animal models for the study of MS, their specific characteristics and limitations.Considering the etiology of multiple sclerosis (MS) is still unknown, experimental models resembling specific aspects of this immune-mediated demyelinating human disease have been developed to increase the understanding of processes related to pathogenesis, disease evolution, evaluation of therapeutic interventions, and demyelination and remyelination mechanisms. Based on the nature of the investigation, biological models may include in vitro, in vivo, and ex vivo assessments. Even though these approaches have disclosed valuable information, every disease animal model has limitations and can only replicate specific features of MS. In vitro and ex vivo models generally do not reflect what occurs in the organism, and in vivo animal models are more likely used; nevertheless, they are able to reproduce only certain stages of the disease. In vivo MS disease animal models in mammals include: experimental autoimmune encephalomyelitis, viral encephalomyelitis, and induced demyelination. This review examines and describes the most common biological disease animal models for the study of MS, their specific characteristics and limitations.
Author Flores‐Díaz, Marietta
Sanabria‐Castro, Alfredo
Alape‐Girón, Alberto
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  surname: Alape‐Girón
  fullname: Alape‐Girón, Alberto
  organization: University of Costa Rica
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experimental autoimmune encephalomyelitis
demyelination
viral encephalomyelitis
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2011; 24
2011; 23
2000; 165
1978; 24
2011; 25
2014; 9
2001; 11
2009; 206
2014; 8
2006; 129
1996; 2
2001; 14
2007; 25
2014; 54
2011; 164
2007; 27
1984; 83
2009; 1305
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2015; 4
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2017; 28
2006; 98
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2006; 9
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2017; 11
2002; 169
2000; 30
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2015; 21
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2002; 22
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2009; 4
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Snippet Considering the etiology of multiple sclerosis (MS) is still unknown, experimental models resembling specific aspects of this immune‐mediated demyelinating...
Considering the etiology of multiple sclerosis (MS) is still unknown, experimental models resembling specific aspects of this immune-mediated demyelinating...
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SubjectTerms Animal diseases
Animal models
Biological models (mathematics)
Demyelination
disease animal models
Disease control
Etiology
Experimental allergic encephalomyelitis
experimental autoimmune encephalomyelitis
In vivo methods and tests
Multiple sclerosis
Myelination
Pathogenesis
Therapeutic applications
viral encephalomyelitis
Title Biological models in multiple sclerosis
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjnr.24528
https://www.ncbi.nlm.nih.gov/pubmed/31571267
https://www.proquest.com/docview/2335371855
https://www.proquest.com/docview/2299768499
Volume 98
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