Ornithine decarboxylase functions in both autophagy and apoptosis in response to ultraviolet B radiation injury

• Published in: Journal of cellular physiology Vol. 237; no. 4; pp. 2140 - 2154
• Main Authors: Liu, Yi‐Liang, Hsiao, I‐Hsin, Lin, Yen‐Hung, Lin, Chih‐Li, Jan, Ming‐Shiou, Hung, Hui‐Chih, Liu, Guang‐Yaw
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2022
• Subjects: Apoptosis; Apoptosis - genetics; Atg12; Atg5; Autophagy; Autophagy - genetics; Autophagy-Related Protein 12 - genetics; Autophagy-Related Protein 5 - genetics; Cell survival; Conjugation; Crosstalk; Exposure; Humans; Markers; Mutants; Ornithine decarboxylase; Ornithine Decarboxylase - genetics; Phagosomes; Poly(ADP-ribose) polymerase; Proteins; Radiation; Radiation Injuries; Site-directed mutagenesis; ultraviolet B; Ultraviolet radiation; Ultraviolet Rays; apoptosis; ornithine decarboxylase; autophagy; ultraviolet B; Atg5; Atg12

We present a mechanism for how ornithine decarboxylase (ODC) regulates the crosstalk between autophagy and apoptosis. In cancer cells, low‐intensity ultraviolet B (UVBL) induces autophagy while high‐intensity UVB (UVBH) induces apoptosis. Overexpression of ODC decreases UVBL‐induced autophagy by inh...