Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

Prostaglandins play a key role in inflammation in a variety of settings. Now, Shuh Narumiya and colleagues show that prostaglandin E2 drives the production of inflammatory T helper cells, and that this can be blocked by inhibiting its EP4 receptor subtype. EP4 inhibitors were also effective at inhib...

Full description

Saved in:
Bibliographic Details
Published inNature medicine Vol. 15; no. 6; pp. 633 - 640
Main Authors Yao, Chengcan, Sakata, Daiji, Esaki, Yoshiyasu, Li, Youxian, Matsuoka, Toshiyuki, Kuroiwa, Kenji, Sugimoto, Yukihiko, Narumiya, Shuh
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.06.2009
Nature Publishing Group
Subjects
Online AccessGet full text

Cover

Loading…