NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR‐199b‐5p‐mediated DDR1 and JAG1 signalling

• Published in: The Journal of pathology Vol. 248; no. 1; pp. 103 - 115
• Main Authors: Chen, Liang‐Yan, Zhi, Zheng, Wang, Lian, Zhao, Yuan‐Yuan, Deng, Min, Liu, Yu‐Hong, Qin, Yan, Tian, Meng‐Meng, Liu, Yao, Shen, Tong, Sun, Li‐Na, Li, Jian‐Ming
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.05.2019; Wiley Subscription Services, Inc
• Subjects: Animals; Cell migration; Cell Movement - physiology; Cell Proliferation - genetics; Circular RNA; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Discoidin Domain Receptor 1 - genetics; Discoidin Domain Receptor 1 - metabolism; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene Silencing; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Humans; Jagged-1 Protein - genetics; Jagged-1 Protein - metabolism; Liver; liver metastasis; Liver Neoplasms, Experimental - genetics; Liver Neoplasms, Experimental - metabolism; Liver Neoplasms, Experimental - pathology; Liver Neoplasms, Experimental - secondary; Male; Metastases; Metastasis; Mice, Inbred BALB C; Mice, Inbred C57BL; MicroRNAs - genetics; miRNA sponge; Neoplasm Invasiveness; Neoplasm Transplantation; Protein-tyrosine kinase receptors; Ribonucleic acid; RNA; RNA, Circular - genetics; RNA, Neoplasm - genetics; Signal Transduction - genetics; Therapeutic applications; Tumors; miRNA sponge; liver metastasis; colorectal cancer; circular RNA

Liver metastasis is the main cause of death in patients with colorectal cancer (CRC). Here, we searched for CRC metastasis‐associated circular RNA in a mouse model of liver metastasis of CRC by using RNA (transcriptome)‐sequencing. We identified a novel and conserved circular RNA, circ‐NSD2, functio...