Neutrophils differentially attenuate immune response to Aspergillus infection through complement receptor 3 and induction of myeloperoxidase

Invasive aspergillosis (IA) remains a major cause of morbidity in immunocompromised hosts. This is due to the inability of the host immunity to respond appropriately to Aspergillus. An established risk factor for IA is neutropenia that is encountered by patients undergoing chemotherapy. Herein, we i...

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Published inCellular microbiology Vol. 20; no. 3; pp. e12798 - n/a
Main Authors Goh, Jessamine G., Ravikumar, Sharada, Win, Mar Soe, Cao, Qiong, Tan, Ai Ling, Lim, Joan H. J., Leong, Winnie, Herbrecht, Raoul, Troke, Peter F., Kullberg, Bart Jan, Netea, Mihai G., Chng, Wee Joo, Dan, Yock Young, Chai, Louis Y. A.
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LanguageEnglish
Published England Hindawi Limited 01.03.2018
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Abstract Invasive aspergillosis (IA) remains a major cause of morbidity in immunocompromised hosts. This is due to the inability of the host immunity to respond appropriately to Aspergillus. An established risk factor for IA is neutropenia that is encountered by patients undergoing chemotherapy. Herein, we investigate the role of neutrophils in modulating host response to Aspergillus. We found that neutrophils had the propensity to suppress proinflammatory cytokine production but through different mechanisms for specific cytokines. Cellular contact was requisite for the modulation of interleukin‐1 beta production by Aspergillus with the involvement of complement receptor 3. On the other hand, inhibition of tumour necrosis factor‐alpha production (TNF‐α) was cell contact‐independent and mediated by secreted myeloperoxidase. Specifically, the inhibition of TNF‐α by myeloperoxidase was through the TLR4 pathway and involved interference with the mRNA transcription of TNF receptor‐associated factor 6/interferon regulatory factor 5. Our study illustrates the extended immune modulatory role of neutrophils beyond its primary phagocytic function. The absence of neutrophils and loss of its inhibitory effect on cytokine production explains the hypercytokinemia seen in neutropenic patients when infected with Aspergillus.
AbstractList Invasive aspergillosis (IA) remains a major cause of morbidity in immunocompromised hosts. This is due to the inability of the host immunity to respond appropriately to Aspergillus. An established risk factor for IA is neutropenia that is encountered by patients undergoing chemotherapy. Herein, we investigate the role of neutrophils in modulating host response to Aspergillus. We found that neutrophils had the propensity to suppress proinflammatory cytokine production but through different mechanisms for specific cytokines. Cellular contact was requisite for the modulation of interleukin‐1 beta production by Aspergillus with the involvement of complement receptor 3. On the other hand, inhibition of tumour necrosis factor‐alpha production (TNF‐α) was cell contact‐independent and mediated by secreted myeloperoxidase. Specifically, the inhibition of TNF‐α by myeloperoxidase was through the TLR4 pathway and involved interference with the mRNA transcription of TNF receptor‐associated factor 6/interferon regulatory factor 5. Our study illustrates the extended immune modulatory role of neutrophils beyond its primary phagocytic function. The absence of neutrophils and loss of its inhibitory effect on cytokine production explains the hypercytokinemia seen in neutropenic patients when infected with Aspergillus.
Invasive aspergillosis (IA) remains a major cause of morbidity in immunocompromised hosts. This is due to the inability of the host immunity to respond appropriately to Aspergillus. An established risk factor for IA is neutropenia that is encountered by patients undergoing chemotherapy. Herein, we investigate the role of neutrophils in modulating host response to Aspergillus. We found that neutrophils had the propensity to suppress proinflammatory cytokine production but through different mechanisms for specific cytokines. Cellular contact was requisite for the modulation of interleukin-1 beta production by Aspergillus with the involvement of complement receptor 3. On the other hand, inhibition of tumour necrosis factor-alpha production (TNF-[alpha]) was cell contact-independent and mediated by secreted myeloperoxidase. Specifically, the inhibition of TNF-[alpha] by myeloperoxidase was through the TLR4 pathway and involved interference with the mRNA transcription of TNF receptor-associated factor 6/interferon regulatory factor 5. Our study illustrates the extended immune modulatory role of neutrophils beyond its primary phagocytic function. The absence of neutrophils and loss of its inhibitory effect on cytokine production explains the hypercytokinemia seen in neutropenic patients when infected with Aspergillus.
Author Herbrecht, Raoul
Lim, Joan H. J.
Win, Mar Soe
Chng, Wee Joo
Kullberg, Bart Jan
Ravikumar, Sharada
Tan, Ai Ling
Netea, Mihai G.
Dan, Yock Young
Goh, Jessamine G.
Cao, Qiong
Troke, Peter F.
Leong, Winnie
Chai, Louis Y. A.
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  surname: Chai
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  email: chailouis@hotmail.com
  organization: National University of Singapore
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crossref_primary_10_1186_s12879_018_3451_8
crossref_primary_10_3390_ijms24129911
crossref_primary_10_1186_s12964_019_0471_y
Cites_doi 10.1038/nature04369
10.1128/IAI.38.2.487-495.1982
10.3389/fimmu.2014.00337
10.1016/S1040-8428(01)00220-7
10.1086/652768
10.1038/nature03308
10.1016/j.molimm.2009.09.018
10.1007/s00011-015-0899-5
10.1056/NEJMoa020191
10.1086/520224
10.1128/IAI.01455-08
10.1086/510592
10.1001/archinternmed.2011.374
10.1111/j.1600-6143.2009.02887.x
10.1371/journal.ppat.1004985
10.1172/JCI110489
10.4049/jimmunol.173.5.2913
10.4049/jimmunol.1103551
10.1016/j.it.2009.06.006
10.1016/j.beha.2008.03.004
10.1182/blood-2014-01-551473
10.1111/j.1365-3083.2009.02255.x
10.1086/595846
10.1086/656527
10.2217/fmb.10.158
10.3324/haematol.2011.053363
10.1182/blood-2002-05-1496
10.1038/bmt.2008.270
10.1007/s00011-013-0656-6
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Issue 3
Keywords immunomodulation
neutropenia
invasive aspergillosis
interleukin-1 beta
tumour necrosis factor-alpha
Language English
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References 2009; 47
2009; 69
1982; 38
2006; 439
2012; 189
2009; 43
1999; 29
2010; 202
2013; 62
2005; 434
2015; 11
2011; 6
2011; 171
2012; 97
2009; 48
2009; 77
1982; 69
2014; 5
2009; 30
2004; 173
2002; 100
2002; 44
2016; 65
2002; 347
2008; 21
2015
2009; 4
2007; 44
2010; 50
2014; 124
Diamond (10.1111/cmi.12798-BIB0007|cmi12798-cit-0008) 1982; 38
Gresnigt (10.1111/cmi.12798-BIB0013|cmi12798-cit-0014) 2012; 189
Velden (10.1111/cmi.12798-BIB0030|cmi12798-cit-0031) 2009; 43
Homme (10.1111/cmi.12798-BIB0017|cmi12798-cit-0018) 2013; 62
Herbrecht (10.1111/cmi.12798-BIB0016|cmi12798-cit-0017) 2002; 347
Pagano (10.1111/cmi.12798-BIB0025|cmi12798-cit-0026) 2011; 171
Hacker (10.1111/cmi.12798-BIB0014|cmi12798-cit-0015) 2006; 439
Chai (10.1111/cmi.12798-BIB0006|cmi12798-cit-0007) 2011; 6
Gazendam (10.1111/cmi.12798-BIB0011|cmi12798-cit-0012) 2014; 124
Marr (10.1111/cmi.12798-BIB0021|cmi12798-cit-0022) 2002; 100
Bruggen (10.1111/cmi.12798-BIB0002|cmi12798-cit-0003) 2009; 47
Castellheim (10.1111/cmi.12798-BIB0003|cmi12798-cit-0004) 2009; 69
Dickinson (10.1111/cmi.12798-BIB0008|cmi12798-cit-0009) 2008; 21
Takaoka (10.1111/cmi.12798-BIB0028|cmi12798-cit-0029) 2005; 434
Fishman (10.1111/cmi.12798-BIB0010|cmi12798-cit-0011) 2009; 4
Neofytos (10.1111/cmi.12798-BIB0023|cmi12798-cit-0024) 2009; 48
Upton (10.1111/cmi.12798-BIB0029|cmi12798-cit-0030) 2007; 44
Soehnlein (10.1111/cmi.12798-BIB0027|cmi12798-cit-0028) 2009; 30
Baddley (10.1111/cmi.12798-BIB0001|cmi12798-cit-0002) 2010; 50
Chai (10.1111/cmi.12798-BIB0004|cmi12798-cit-0005) 2009; 77
Endo (10.1111/cmi.12798-BIB0009|cmi12798-cit-0010) 2016; 65
Oude Nijhuis (10.1111/cmi.12798-BIB0024|cmi12798-cit-0025) 2002; 44
Chai (10.1111/cmi.12798-BIB0005|cmi12798-cit-0006) 2010; 202
Gohda (10.1111/cmi.12798-BIB0012|cmi12798-cit-0013) 2004; 173
10.1111/cmi.12798-BIB0020|cmi12798-cit-0021
Lehrnbecher (10.1111/cmi.12798-BIB0019|cmi12798-cit-0020) 1999; 29
Schaffner (10.1111/cmi.12798-BIB0026|cmi12798-cit-0027) 1982; 69
Huang (10.1111/cmi.12798-BIB0018|cmi12798-cit-0019) 2015; 11
Melenhorst (10.1111/cmi.12798-BIB0022|cmi12798-cit-0023) 2012; 97
Heidegger (10.1111/cmi.12798-BIB0015|cmi12798-cit-0016) 2014; 5
References_xml – volume: 347
  start-page: 408
  issue: 6
  year: 2002
  end-page: 415
  article-title: Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis
  publication-title: The New England Journal of Medicine
– volume: 50
  start-page: 1559
  issue: 12
  year: 2010
  end-page: 1567
  article-title: Factors associated with mortality in transplant patients with invasive aspergillosis
  publication-title: Clinical Infectious Diseases
– volume: 100
  start-page: 4358
  issue: 13
  year: 2002
  end-page: 4366
  article-title: Invasive aspergillosis in allogeneic stem cell transplant recipients: Changes in epidemiology and risk factors
  publication-title: Blood
– volume: 171
  start-page: 1502
  issue: 16
  year: 2011
  end-page: 1503
  article-title: Etiology of febrile episodes in patients with acute myeloid leukemia: Results from the Hema e‐chart registry
  publication-title: Archives of Internal Medicine
– volume: 69
  start-page: 617
  issue: 3
  year: 1982
  end-page: 631
  article-title: Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to . Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes
  publication-title: The Journal of Clinical Investigation
– volume: 21
  start-page: 149
  issue: 2
  year: 2008
  end-page: 164
  article-title: Polymorphisms of cytokine and innate immunity genes and GVHD
  publication-title: Best Practice & Research. Clinical Haematology
– volume: 44
  start-page: 531
  issue: 4
  year: 2007
  end-page: 540
  article-title: Invasive aspergillosis following hematopoietic cell transplantation: Outcomes and prognostic factors associated with mortality
  publication-title: Clinical Infectious Diseases
– volume: 69
  start-page: 479
  issue: 6
  year: 2009
  end-page: 491
  article-title: Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis
  publication-title: Scandinavian Journal of Immunology
– volume: 439
  start-page: 204
  issue: 7073
  year: 2006
  end-page: 207
  article-title: Specificity in toll‐like receptor signalling through distinct effector functions of TRAF3 and TRAF6
  publication-title: Nature
– volume: 62
  start-page: 981
  issue: 11
  year: 2013
  end-page: 990
  article-title: Myeloperoxidase deficiency in mice exacerbates lung inflammation induced by nonviable Candida Albicans
  publication-title: Inflammation Research
– volume: 43
  start-page: 55
  issue: 1
  year: 2009
  end-page: 60
  article-title: Febrile mucositis in haematopoietic SCT recipients
  publication-title: Bone Marrow Transplantation
– volume: 29
  start-page: 414
  issue: 2
  year: 1999
  end-page: 419
  article-title: Assessment of measuring circulating levels of interleukin‐6, interleukin‐8, C‐reactive protein, soluble Fc gamma receptor type III, and mannose‐binding protein in febrile children with cancer and neutropenia
  publication-title: Clinical Infectious Diseases
– volume: 48
  start-page: 265
  issue: 3
  year: 2009
  end-page: 273
  article-title: Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: Analysis of multicenter prospective antifungal therapy (PATH) alliance registry
  publication-title: Clinical Infectious Diseases
– volume: 97
  start-page: 867
  issue: 6
  year: 2012
  end-page: 873
  article-title: Cytopenia and leukocyte recovery shape cytokine fluctuations after myeloablative allogeneic hematopoietic stem cell transplantation
  publication-title: Haematologica
– volume: 5
  year: 2014
  article-title: The role of pattern‐recognition receptors in graft‐versus‐host disease and graft‐versus‐leukemia after allogeneic stem cell transplantation
  publication-title: Frontiers in Immunology
– volume: 38
  start-page: 487
  issue: 2
  year: 1982
  end-page: 495
  article-title: Damage to and hyphae by oxidative and nonoxidative microbicidal products of human neutrophils in vitro
  publication-title: Infection and Immunity
– volume: 30
  start-page: 538
  issue: 11
  year: 2009
  end-page: 546
  article-title: Neutrophil granule proteins tune monocytic cell function
  publication-title: Trends in Immunology
– volume: 11
  issue: 7
  year: 2015
  article-title: CR3 and Dectin‐1 collaborate in macrophage cytokine response through association on lipid rafts and activation of Syk‐JNK‐AP‐1 pathway
  publication-title: PLoS Pathogens
– volume: 189
  start-page: 4806
  issue: 10
  year: 2012
  end-page: 4815
  article-title: Neutrophil‐mediated inhibition of proinflammatory cytokine responses
  publication-title: Journal of Immunology
– volume: 65
  start-page: 151
  issue: 2
  year: 2016
  end-page: 159
  article-title: Myeloperoxidase negatively regulates the expression of proinflammatory cytokines and chemokines by zymosan‐induced mouse neutrophils
  publication-title: Inflammation Research
– volume: 77
  start-page: 2184
  issue: 5
  year: 2009
  end-page: 2192
  article-title: Modulation of toll‐like receptor 2 (TLR2) and TLR4 responses by Aspergillus fumigatus
  publication-title: Infection and Immunity
– volume: 434
  start-page: 243
  issue: 7030
  year: 2005
  end-page: 249
  article-title: Integral role of IRF‐5 in the gene induction programme activated by toll‐like receptors
  publication-title: Nature
– volume: 47
  start-page: 575
  issue: 2–3
  year: 2009
  end-page: 581
  article-title: Complement receptor 3, not Dectin‐1, is the major receptor on human neutrophils for beta‐glucan‐bearing particles
  publication-title: Molecular Immunology
– volume: 44
  start-page: 163
  issue: 2
  year: 2002
  end-page: 174
  article-title: Fever and neutropenia in cancer patients: The diagnostic role of cytokines in risk assessment strategies
  publication-title: Critical Reviews in Oncology/Hematology
– volume: 6
  start-page: 73
  issue: 1
  year: 2011
  end-page: 83
  article-title: Immune response to aspergillus fumigatus in compromised hosts: From bedside to bench
  publication-title: Future Microbiology
– volume: 4
  start-page: S3
  year: 2009
  end-page: 6
  article-title: Introduction: Infection in solid organ transplant recipients
  publication-title: American Journal of Transplantation
– volume: 202
  start-page: 1454
  issue: 9
  year: 2010
  end-page: 1462
  article-title: Early proinflammatory cytokines and C‐reactive protein trends as predictors of outcome in invasive aspergillosis
  publication-title: The Journal of Infectious Diseases
– volume: 124
  start-page: 590
  issue: 4
  year: 2014
  end-page: 597
  article-title: Two independent killing mechanisms of Candida Albicans by human neutrophils: Evidence from innate immunity defects
  publication-title: Blood
– year: 2015
– volume: 173
  start-page: 2913
  issue: 5
  year: 2004
  end-page: 2917
  article-title: Cutting edge: TNFR‐associated factor (TRAF) 6 is essential for MyD88‐dependent pathway but not toll/IL‐1 receptor domain‐containing adaptor‐inducing IFN‐beta (TRIF)‐dependent pathway in TLR signaling
  publication-title: Journal of Immunology
– volume: 439
  start-page: 204
  issue: 7073
  year: 2006
  ident: 10.1111/cmi.12798-BIB0014|cmi12798-cit-0015
  article-title: Specificity in toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
  publication-title: Nature
  doi: 10.1038/nature04369
  contributor:
    fullname: Hacker
– volume: 38
  start-page: 487
  issue: 2
  year: 1982
  ident: 10.1111/cmi.12798-BIB0007|cmi12798-cit-0008
  article-title: Damage to Aspergillus fumigatus and Rhizopus oryzae hyphae by oxidative and nonoxidative microbicidal products of human neutrophils in vitro
  publication-title: Infection and Immunity
  doi: 10.1128/IAI.38.2.487-495.1982
  contributor:
    fullname: Diamond
– volume: 5
  start-page: 337
  year: 2014
  ident: 10.1111/cmi.12798-BIB0015|cmi12798-cit-0016
  article-title: The role of pattern-recognition receptors in graft-versus-host disease and graft-versus-leukemia after allogeneic stem cell transplantation
  publication-title: Frontiers in Immunology
  doi: 10.3389/fimmu.2014.00337
  contributor:
    fullname: Heidegger
– volume: 44
  start-page: 163
  issue: 2
  year: 2002
  ident: 10.1111/cmi.12798-BIB0024|cmi12798-cit-0025
  article-title: Fever and neutropenia in cancer patients: The diagnostic role of cytokines in risk assessment strategies
  publication-title: Critical Reviews in Oncology/Hematology
  doi: 10.1016/S1040-8428(01)00220-7
  contributor:
    fullname: Oude Nijhuis
– volume: 50
  start-page: 1559
  issue: 12
  year: 2010
  ident: 10.1111/cmi.12798-BIB0001|cmi12798-cit-0002
  article-title: Factors associated with mortality in transplant patients with invasive aspergillosis
  publication-title: Clinical Infectious Diseases
  doi: 10.1086/652768
  contributor:
    fullname: Baddley
– volume: 434
  start-page: 243
  issue: 7030
  year: 2005
  ident: 10.1111/cmi.12798-BIB0028|cmi12798-cit-0029
  article-title: Integral role of IRF-5 in the gene induction programme activated by toll-like receptors
  publication-title: Nature
  doi: 10.1038/nature03308
  contributor:
    fullname: Takaoka
– volume: 47
  start-page: 575
  issue: 2-3
  year: 2009
  ident: 10.1111/cmi.12798-BIB0002|cmi12798-cit-0003
  article-title: Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles
  publication-title: Molecular Immunology
  doi: 10.1016/j.molimm.2009.09.018
  contributor:
    fullname: Bruggen
– volume: 65
  start-page: 151
  issue: 2
  year: 2016
  ident: 10.1111/cmi.12798-BIB0009|cmi12798-cit-0010
  article-title: Myeloperoxidase negatively regulates the expression of proinflammatory cytokines and chemokines by zymosan-induced mouse neutrophils
  publication-title: Inflammation Research
  doi: 10.1007/s00011-015-0899-5
  contributor:
    fullname: Endo
– volume: 347
  start-page: 408
  issue: 6
  year: 2002
  ident: 10.1111/cmi.12798-BIB0016|cmi12798-cit-0017
  article-title: Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis
  publication-title: The New England Journal of Medicine
  doi: 10.1056/NEJMoa020191
  contributor:
    fullname: Herbrecht
– volume: 29
  start-page: 414
  issue: 2
  year: 1999
  ident: 10.1111/cmi.12798-BIB0019|cmi12798-cit-0020
  article-title: Assessment of measuring circulating levels of interleukin-6, interleukin-8, C-reactive protein, soluble Fc gamma receptor type III, and mannose-binding protein in febrile children with cancer and neutropenia
  publication-title: Clinical Infectious Diseases
  doi: 10.1086/520224
  contributor:
    fullname: Lehrnbecher
– volume: 77
  start-page: 2184
  issue: 5
  year: 2009
  ident: 10.1111/cmi.12798-BIB0004|cmi12798-cit-0005
  article-title: Modulation of toll-like receptor 2 (TLR2) and TLR4 responses by Aspergillus fumigatus
  publication-title: Infection and Immunity
  doi: 10.1128/IAI.01455-08
  contributor:
    fullname: Chai
– ident: 10.1111/cmi.12798-BIB0020|cmi12798-cit-0021
– volume: 44
  start-page: 531
  issue: 4
  year: 2007
  ident: 10.1111/cmi.12798-BIB0029|cmi12798-cit-0030
  article-title: Invasive aspergillosis following hematopoietic cell transplantation: Outcomes and prognostic factors associated with mortality
  publication-title: Clinical Infectious Diseases
  doi: 10.1086/510592
  contributor:
    fullname: Upton
– volume: 171
  start-page: 1502
  issue: 16
  year: 2011
  ident: 10.1111/cmi.12798-BIB0025|cmi12798-cit-0026
  article-title: Etiology of febrile episodes in patients with acute myeloid leukemia: Results from the Hema e-chart registry
  publication-title: Archives of Internal Medicine
  doi: 10.1001/archinternmed.2011.374
  contributor:
    fullname: Pagano
– volume: 4
  start-page: S3
  year: 2009
  ident: 10.1111/cmi.12798-BIB0010|cmi12798-cit-0011
  article-title: Introduction: Infection in solid organ transplant recipients
  publication-title: American Journal of Transplantation
  doi: 10.1111/j.1600-6143.2009.02887.x
  contributor:
    fullname: Fishman
– volume: 11
  start-page: e1004985
  issue: 7
  year: 2015
  ident: 10.1111/cmi.12798-BIB0018|cmi12798-cit-0019
  article-title: CR3 and Dectin-1 collaborate in macrophage cytokine response through association on lipid rafts and activation of Syk-JNK-AP-1 pathway
  publication-title: PLoS Pathogens
  doi: 10.1371/journal.ppat.1004985
  contributor:
    fullname: Huang
– volume: 69
  start-page: 617
  issue: 3
  year: 1982
  ident: 10.1111/cmi.12798-BIB0026|cmi12798-cit-0027
  article-title: Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes
  publication-title: The Journal of Clinical Investigation
  doi: 10.1172/JCI110489
  contributor:
    fullname: Schaffner
– volume: 173
  start-page: 2913
  issue: 5
  year: 2004
  ident: 10.1111/cmi.12798-BIB0012|cmi12798-cit-0013
  article-title: Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling
  publication-title: Journal of Immunology
  doi: 10.4049/jimmunol.173.5.2913
  contributor:
    fullname: Gohda
– volume: 189
  start-page: 4806
  issue: 10
  year: 2012
  ident: 10.1111/cmi.12798-BIB0013|cmi12798-cit-0014
  article-title: Neutrophil-mediated inhibition of proinflammatory cytokine responses
  publication-title: Journal of Immunology
  doi: 10.4049/jimmunol.1103551
  contributor:
    fullname: Gresnigt
– volume: 30
  start-page: 538
  issue: 11
  year: 2009
  ident: 10.1111/cmi.12798-BIB0027|cmi12798-cit-0028
  article-title: Neutrophil granule proteins tune monocytic cell function
  publication-title: Trends in Immunology
  doi: 10.1016/j.it.2009.06.006
  contributor:
    fullname: Soehnlein
– volume: 21
  start-page: 149
  issue: 2
  year: 2008
  ident: 10.1111/cmi.12798-BIB0008|cmi12798-cit-0009
  article-title: Polymorphisms of cytokine and innate immunity genes and GVHD
  publication-title: Best Practice & Research. Clinical Haematology
  doi: 10.1016/j.beha.2008.03.004
  contributor:
    fullname: Dickinson
– volume: 124
  start-page: 590
  issue: 4
  year: 2014
  ident: 10.1111/cmi.12798-BIB0011|cmi12798-cit-0012
  article-title: Two independent killing mechanisms of Candida Albicans by human neutrophils: Evidence from innate immunity defects
  publication-title: Blood
  doi: 10.1182/blood-2014-01-551473
  contributor:
    fullname: Gazendam
– volume: 69
  start-page: 479
  issue: 6
  year: 2009
  ident: 10.1111/cmi.12798-BIB0003|cmi12798-cit-0004
  article-title: Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis
  publication-title: Scandinavian Journal of Immunology
  doi: 10.1111/j.1365-3083.2009.02255.x
  contributor:
    fullname: Castellheim
– volume: 48
  start-page: 265
  issue: 3
  year: 2009
  ident: 10.1111/cmi.12798-BIB0023|cmi12798-cit-0024
  article-title: Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: Analysis of multicenter prospective antifungal therapy (PATH) alliance registry
  publication-title: Clinical Infectious Diseases
  doi: 10.1086/595846
  contributor:
    fullname: Neofytos
– volume: 202
  start-page: 1454
  issue: 9
  year: 2010
  ident: 10.1111/cmi.12798-BIB0005|cmi12798-cit-0006
  article-title: Early proinflammatory cytokines and C-reactive protein trends as predictors of outcome in invasive aspergillosis
  publication-title: The Journal of Infectious Diseases
  doi: 10.1086/656527
  contributor:
    fullname: Chai
– volume: 6
  start-page: 73
  issue: 1
  year: 2011
  ident: 10.1111/cmi.12798-BIB0006|cmi12798-cit-0007
  article-title: Immune response to aspergillus fumigatus in compromised hosts: From bedside to bench
  publication-title: Future Microbiology
  doi: 10.2217/fmb.10.158
  contributor:
    fullname: Chai
– volume: 97
  start-page: 867
  issue: 6
  year: 2012
  ident: 10.1111/cmi.12798-BIB0022|cmi12798-cit-0023
  article-title: Cytopenia and leukocyte recovery shape cytokine fluctuations after myeloablative allogeneic hematopoietic stem cell transplantation
  publication-title: Haematologica
  doi: 10.3324/haematol.2011.053363
  contributor:
    fullname: Melenhorst
– volume: 100
  start-page: 4358
  issue: 13
  year: 2002
  ident: 10.1111/cmi.12798-BIB0021|cmi12798-cit-0022
  article-title: Invasive aspergillosis in allogeneic stem cell transplant recipients: Changes in epidemiology and risk factors
  publication-title: Blood
  doi: 10.1182/blood-2002-05-1496
  contributor:
    fullname: Marr
– volume: 43
  start-page: 55
  issue: 1
  year: 2009
  ident: 10.1111/cmi.12798-BIB0030|cmi12798-cit-0031
  article-title: Febrile mucositis in haematopoietic SCT recipients
  publication-title: Bone Marrow Transplantation
  doi: 10.1038/bmt.2008.270
  contributor:
    fullname: Velden
– volume: 62
  start-page: 981
  issue: 11
  year: 2013
  ident: 10.1111/cmi.12798-BIB0017|cmi12798-cit-0018
  article-title: Myeloperoxidase deficiency in mice exacerbates lung inflammation induced by nonviable Candida Albicans
  publication-title: Inflammation Research
  doi: 10.1007/s00011-013-0656-6
  contributor:
    fullname: Homme
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Snippet Invasive aspergillosis (IA) remains a major cause of morbidity in immunocompromised hosts. This is due to the inability of the host immunity to respond...
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wiley
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StartPage e12798
SubjectTerms Aspergillosis
Aspergillosis - immunology
Aspergillus
Cell Adhesion Molecules - metabolism
Cells, Cultured
Cellular manufacture
Chemotherapy
Complement receptor 3
Cytokines
Humans
Immune response
Immune system
Immunity
Immunocompromised hosts
immunomodulation
Immunomodulation - immunology
Immunomodulation - physiology
Inflammation
Inhibition
Interferon
Interferon regulatory factor
Interleukin 1
Interleukin-1beta - metabolism
interleukin‐1 beta
invasive aspergillosis
Leukocytes (neutrophilic)
Microscopy, Confocal
Morbidity
Neutropenia
Neutropenia - immunology
Neutropenia - metabolism
Neutrophils
Neutrophils - immunology
Neutrophils - metabolism
Neutrophils - physiology
Patients
Peroxidase
Peroxidase - metabolism
Phagocytes
Risk factors
TLR4 protein
Toll-like receptors
Tumor necrosis factor
Tumor necrosis factor receptors
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
Tumors
tumour necrosis factor‐alpha
Title Neutrophils differentially attenuate immune response to Aspergillus infection through complement receptor 3 and induction of myeloperoxidase
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcmi.12798
https://www.ncbi.nlm.nih.gov/pubmed/29088499
https://www.proquest.com/docview/1999438053
https://search.proquest.com/docview/1958542466
Volume 20
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