Habitual exercisers versus sedentary subjects with Parkinson's Disease: Multimodal PET and fMRI study

• Published in: Movement disorders Vol. 33; no. 12; pp. 1945 - 1950
• Main Authors: Sacheli, Matthew A., Murray, Danielle K., Vafai, Nasim, Cherkasova, Mariya V., Dinelle, Katie, Shahinfard, Elham, Neilson, Nicole, McKenzie, Jessamyn, Schulzer, Michael, Appel‐Cresswell, Silke, McKeown, Martin J., Sossi, Vesna, Jon Stoessl, A.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2018
• Subjects: Aged; Apathy; Caudate Nucleus - pathology; Caudate Nucleus - physiopathology; Caudate-putamen; Dopamine; Dopamine - metabolism; dopamine release; Emotional behavior; Exercise; Female; function magnetic resonance imaging; Functional magnetic resonance imaging; Humans; Magnetic Resonance Imaging - methods; Male; Mental depression; Middle Aged; Motor task performance; Movement disorders; Multimodal Imaging - methods; Neostriatum; Neurodegenerative diseases; Parkinson Disease - complications; Parkinson Disease - diagnostic imaging; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Parkinson's disease; Positron-Emission Tomography; Preservation; Raclopride; Reinforcement; Reward; Sedentary behavior; Ventral Striatum - pathology; Ventral Striatum - physiopathology; exercise; Parkinson's disease; function magnetic resonance imaging; positron emission tomography; dopamine release

ABSTRACT Background The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum. Objective To examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD. Methods Eight habitual exerc...