Habitual exercisers versus sedentary subjects with Parkinson's Disease: Multimodal PET and fMRI study
ABSTRACT Background The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum. Objective To examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD. Methods Eight habitual exerc...
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| Published in | Movement disorders Vol. 33; no. 12; pp. 1945 - 1950 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.12.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | ABSTRACT
Background
The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum.
Objective
To examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD.
Methods
Eight habitual exercisers and 9 sedentary subjects completed [11C]raclopride PET scans before and after stationary cycling to determine exercise‐induced release of endogenous DA in the dorsal striatum. Additionally, functional MRI assessed ventral striatum activation during reward anticipation. All participants completed motor (UPDRS III; finger tapping; and timed‐up‐and‐go) and nonmotor (Beck Depression Inventory; Starkstein Apathy Scale) assessments.
Results
[11C]Raclopride analysis before and after stationary cycling demonstrated greater DA release in the caudate nuclei of habitual exercisers compared to sedentary subjects (P < 0.05). Habitual exercisers revealed greater activation of ventral striatum during the functional MRI reward task (P < 0.05) and lower apathy (P < 0.05) and bradykinesia (P < 0.05) scores versus sedentary subjects.
Conclusions
Habitual exercise is associated with preservation of motor and nonmotor function, possibly mediated by increased DA release. This study formulates a foundation for prospective, randomized controlled studies. © 2018 International Parkinson and Movement Disorder Society |
|---|---|
| AbstractList | BackgroundThe benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum.ObjectiveTo examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD.MethodsEight habitual exercisers and 9 sedentary subjects completed [11C]raclopride PET scans before and after stationary cycling to determine exercise‐induced release of endogenous DA in the dorsal striatum. Additionally, functional MRI assessed ventral striatum activation during reward anticipation. All participants completed motor (UPDRS III; finger tapping; and timed‐up‐and‐go) and nonmotor (Beck Depression Inventory; Starkstein Apathy Scale) assessments.Results[11C]Raclopride analysis before and after stationary cycling demonstrated greater DA release in the caudate nuclei of habitual exercisers compared to sedentary subjects (P < 0.05). Habitual exercisers revealed greater activation of ventral striatum during the functional MRI reward task (P < 0.05) and lower apathy (P < 0.05) and bradykinesia (P < 0.05) scores versus sedentary subjects.ConclusionsHabitual exercise is associated with preservation of motor and nonmotor function, possibly mediated by increased DA release. This study formulates a foundation for prospective, randomized controlled studies. © 2018 International Parkinson and Movement Disorder Society ABSTRACT Background The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum. Objective To examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD. Methods Eight habitual exercisers and 9 sedentary subjects completed [11C]raclopride PET scans before and after stationary cycling to determine exercise‐induced release of endogenous DA in the dorsal striatum. Additionally, functional MRI assessed ventral striatum activation during reward anticipation. All participants completed motor (UPDRS III; finger tapping; and timed‐up‐and‐go) and nonmotor (Beck Depression Inventory; Starkstein Apathy Scale) assessments. Results [11C]Raclopride analysis before and after stationary cycling demonstrated greater DA release in the caudate nuclei of habitual exercisers compared to sedentary subjects (P < 0.05). Habitual exercisers revealed greater activation of ventral striatum during the functional MRI reward task (P < 0.05) and lower apathy (P < 0.05) and bradykinesia (P < 0.05) scores versus sedentary subjects. Conclusions Habitual exercise is associated with preservation of motor and nonmotor function, possibly mediated by increased DA release. This study formulates a foundation for prospective, randomized controlled studies. © 2018 International Parkinson and Movement Disorder Society The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum.BACKGROUNDThe benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum.To examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD.OBJECTIVETo examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD.Eight habitual exercisers and 9 sedentary subjects completed [11 C]raclopride PET scans before and after stationary cycling to determine exercise-induced release of endogenous DA in the dorsal striatum. Additionally, functional MRI assessed ventral striatum activation during reward anticipation. All participants completed motor (UPDRS III; finger tapping; and timed-up-and-go) and nonmotor (Beck Depression Inventory; Starkstein Apathy Scale) assessments.METHODSEight habitual exercisers and 9 sedentary subjects completed [11 C]raclopride PET scans before and after stationary cycling to determine exercise-induced release of endogenous DA in the dorsal striatum. Additionally, functional MRI assessed ventral striatum activation during reward anticipation. All participants completed motor (UPDRS III; finger tapping; and timed-up-and-go) and nonmotor (Beck Depression Inventory; Starkstein Apathy Scale) assessments.[11 C]Raclopride analysis before and after stationary cycling demonstrated greater DA release in the caudate nuclei of habitual exercisers compared to sedentary subjects (P < 0.05). Habitual exercisers revealed greater activation of ventral striatum during the functional MRI reward task (P < 0.05) and lower apathy (P < 0.05) and bradykinesia (P < 0.05) scores versus sedentary subjects.RESULTS[11 C]Raclopride analysis before and after stationary cycling demonstrated greater DA release in the caudate nuclei of habitual exercisers compared to sedentary subjects (P < 0.05). Habitual exercisers revealed greater activation of ventral striatum during the functional MRI reward task (P < 0.05) and lower apathy (P < 0.05) and bradykinesia (P < 0.05) scores versus sedentary subjects.Habitual exercise is associated with preservation of motor and nonmotor function, possibly mediated by increased DA release. This study formulates a foundation for prospective, randomized controlled studies. © 2018 International Parkinson and Movement Disorder Society.CONCLUSIONSHabitual exercise is associated with preservation of motor and nonmotor function, possibly mediated by increased DA release. This study formulates a foundation for prospective, randomized controlled studies. © 2018 International Parkinson and Movement Disorder Society. The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum. To examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD. Eight habitual exercisers and 9 sedentary subjects completed [ C]raclopride PET scans before and after stationary cycling to determine exercise-induced release of endogenous DA in the dorsal striatum. Additionally, functional MRI assessed ventral striatum activation during reward anticipation. All participants completed motor (UPDRS III; finger tapping; and timed-up-and-go) and nonmotor (Beck Depression Inventory; Starkstein Apathy Scale) assessments. [ C]Raclopride analysis before and after stationary cycling demonstrated greater DA release in the caudate nuclei of habitual exercisers compared to sedentary subjects (P < 0.05). Habitual exercisers revealed greater activation of ventral striatum during the functional MRI reward task (P < 0.05) and lower apathy (P < 0.05) and bradykinesia (P < 0.05) scores versus sedentary subjects. Habitual exercise is associated with preservation of motor and nonmotor function, possibly mediated by increased DA release. This study formulates a foundation for prospective, randomized controlled studies. © 2018 International Parkinson and Movement Disorder Society. |
| Author | McKeown, Martin J. Sossi, Vesna Vafai, Nasim McKenzie, Jessamyn Jon Stoessl, A. Schulzer, Michael Appel‐Cresswell, Silke Shahinfard, Elham Sacheli, Matthew A. Murray, Danielle K. Dinelle, Katie Cherkasova, Mariya V. Neilson, Nicole |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30376184$$D View this record in MEDLINE/PubMed |
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| Notes | Matthew Sacheli was supported by Parkinson Canada. A.J.S. has received research support from University of British Columbia, Canada Research Chairs, Pacific Parkinson's Research Institute, Michael J. Fox Foundation, and Weston Brain Institute and honoraria for speaking and consulting from AbbVie, and chair the DSMB for a trial of gene therapy sponsored by Voyager Therapeutics. Full financial disclosures and author roles may be found in the online version of this article. This study was funded by the Pacific Parkinson's Research Institute. Relevant conflicts of interest/financial disclosures Funding agencies ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| Snippet | ABSTRACT
Background
The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum.
Objective
To examine differences in... The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum. To examine differences in DA release, reward signaling,... BackgroundThe benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum.ObjectiveTo examine differences in DA release,... The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum.BACKGROUNDThe benefits of exercise in PD have been... |
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| SubjectTerms | Aged Apathy Caudate Nucleus - pathology Caudate Nucleus - physiopathology Caudate-putamen Dopamine Dopamine - metabolism dopamine release Emotional behavior Exercise Female function magnetic resonance imaging Functional magnetic resonance imaging Humans Magnetic Resonance Imaging - methods Male Mental depression Middle Aged Motor task performance Movement disorders Multimodal Imaging - methods Neostriatum Neurodegenerative diseases Parkinson Disease - complications Parkinson Disease - diagnostic imaging Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson's disease Positron-Emission Tomography Preservation Raclopride Reinforcement Reward Sedentary behavior Ventral Striatum - pathology Ventral Striatum - physiopathology |
| Title | Habitual exercisers versus sedentary subjects with Parkinson's Disease: Multimodal PET and fMRI study |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmds.27498 https://www.ncbi.nlm.nih.gov/pubmed/30376184 https://www.proquest.com/docview/2159705674 https://www.proquest.com/docview/2127196767 |
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