Oxymatrine ameliorates insulin resistance in rats with type 2 diabetes by regulating the expression of KSRP, PETN, and AKT in the liver

• Published in: Journal of cellular biochemistry Vol. 120; no. 9; pp. 16185 - 16194
• Main Authors: Zuo, Mei‐Ling, Wang, Ai‐Ping, Tian, Ying, Mao, Li, Song, Gui‐Lin, Yang, Zhong‐Bao
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2019
• Subjects: AKT; AKT protein; Antidiabetics; Blood; Blood glucose; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Glucose; Glycogen; High fat diet; Insulin; Insulin resistance; KH‐type splicing regulatory protein (KSRP); Liver; oxymatrine; PETN; Phosphorylation; PTEN protein; Sensitivity; Splicing; Streptozocin; Synthesis; type 2 diabetes mellitus (T2DM); oxymatrine; AKT; PETN; KH-type splicing regulatory protein (KSRP); insulin resistance; type 2 diabetes mellitus (T2DM)

Insulin resistance plays a key role in the development and progression of type 2 diabetes mellitus (T2DM). Recent studies found that insulin resistance was associated with the dysfunction of KH‐type splicing regulatory protein (KSRP) expression and AKT pathway, and that oxymatrine possesses an antid...