Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases

• Published in: Journal of cellular physiology Vol. 235; no. 4; pp. 3207 - 3221
• Main Authors: Lu, Fangfang, Lan, Zhixin, Xin, Zhaoqi, He, Chunrong, Guo, Zimeng, Xia, Xiaobo, Hu, Tu
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2020
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Apoptosis; Apoptosis - genetics; Apoptosis Regulatory Proteins - genetics; Autoimmune diseases; Calcium-Binding Proteins - genetics; CARD Signaling Adaptor Proteins - genetics; Caspase; caspases; Caspases - genetics; Caspases - metabolism; Cell death; Cell size; Cytokines; Cytotoxicity; GSDMD; Humans; Infectious diseases; Inflammasomes; Inflammasomes - genetics; Inflammasomes - metabolism; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Interleukin-18 - genetics; Interleukin-1beta - genetics; Intracellular Signaling Peptides and Proteins - genetics; Membranes; Microorganisms; Molecular modelling; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; Oligomerization; Phosphate-Binding Proteins - genetics; Plasma membranes; Pore formation; Pyrin protein; Pyroptosis; Pyroptosis - genetics; Sepsis; Substrates; GSDMD; pyroptosis; inflammasomes; caspases

Pyroptosis is a form of necrotic and inflammatory programmed cell death, which could be characterized by cell swelling, pore formation on plasma membranes, and release of proinflammatory cytokines (IL‐1β and IL‐18). The process of pyroptosis presents as dual effects: protecting multicellular organis...