Exosomal tumor necrosis factor‐α from hepatocellular cancer cells (Huh‐7) promote osteoclast differentiation

• Published in: Journal of cellular biochemistry Vol. 122; no. 11; pp. 1749 - 1760
• Main Authors: Li, Ching‐Hao, Palanisamy, Kalaiselvi, Li, Xin, Yu, Shao‐Hua, Wang, I‐Kuan, Li, Chi‐Yuan, Sun, Kuo‐Ting
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2021
• Subjects: Animals; Biomedical materials; Bone cancer; Bone diseases; Bone growth; Bone resorption; Cathepsin K; Cathepsin K - metabolism; CD63 antigen; Cell differentiation; Cell Differentiation - physiology; Cell interactions; Cellular communication; Culture Media, Conditioned - pharmacology; Exosomes; Exosomes - metabolism; Exosomes - pathology; hepatocellular cancer; Hepatocytes; Humans; inflammation; Liver cancer; Liver Neoplasms - pathology; Markers; Metastases; Mice; Necrosis; NF-kappa B - metabolism; Osteoclastogenesis; Osteoclasts; Osteoclasts - cytology; Osteolysis; pathological fracture; RAW 264.7 Cells; Regulatory mechanisms (biology); Tartrate-Resistant Acid Phosphatase - metabolism; Therapeutic targets; TRAF6 protein; tumor necrosis factor ɑ; Tumor Necrosis Factor-alpha - metabolism; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-TNF; Tumor necrosis factor-α; tumor necrosis factor ɑ; inflammation; hepatocellular cancer; exosomes; pathological fracture

Bone is the common extra‐hepatic site for cancer metastasis. Hepatic cancer is associated with a higher incidence of pathological fracture. However, this important regulatory mechanism remains unexplored. Thus, exosome‐mediated cell‐cell communication between hepatocellular cancer and bone might be...