Therapeutic effects and mechanisms of Tripterygium wilfordii extracts in rheumatoid arthritis: a systematic review and meta-analysis of preclinical studies

• Published in: Scientific reports Vol. 15; no. 1; pp. 27960 - 26
• Main Authors: Chen, Kai, Chen, Xiaoying, Huang, Shuai, Zhou, Lingling, Zhou, Xueping, Lu, Yan, Feng, Zhe
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.07.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154/436; 692/4023/1670/498; Animal model; Animal species; Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Arthritis, Experimental - drug therapy; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - pathology; Bias; Cartilage; CD4 antigen; Collagen (type II); Disease Models, Animal; Diterpenes; Dosage; Drug dosages; Epoxy Compounds; Helper cells; Humanities and Social Sciences; Humans; Hyperplasia; Immunology; Immunomodulation; Inflammation; Interleukins; Joint diseases; Lymphocytes T; Meta-analysis; multidisciplinary; Pathogenesis; Pentacyclic Triterpenes; Phenanthrenes; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Preclinical studies; Rheumatoid arthritis; Science; Science (multidisciplinary); Software; Statistical analysis; Systematic review; Transforming growth factor-b; Tripterygium - chemistry; Tripterygium wilfordii; Tripterygium wilfordii extracts; Triptolide; Tumor necrosis factor-TNF; Tumor necrosis factor-α; γ-Interferon; Animal model; Preclinical studies; extracts; Rheumatoid arthritis; Meta-analysis; Tripterygium wilfordii extracts

Tripterygium polyglycosides (TG), Triptolide (TP), and Celastrol (CEL), which are extracts from Tripterygium wilfordii Hook F (TwHF), are renowned for their anti-inflammatory and immunomodulatory properties in the treatment of rheumatoid arthritis (RA). However, a comprehensive systematic review and...