Chronologic changes in serum hepatitis B virus DNA, genotypes, surface antigen mutants and reverse transcriptase mutants during 25‐year nationwide immunization in Taiwan
Summary We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog‐resistant (NAr) mutants were assessed in 2853 subj...
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| Published in | Journal of viral hepatitis Vol. 24; no. 8; pp. 645 - 653 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Wiley Subscription Services, Inc
01.08.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1352-0504 1365-2893 1365-2893 |
| DOI | 10.1111/jvh.12687 |
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| Abstract | Summary
We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog‐resistant (NAr) mutants were assessed in 2853 subjects (<25 years old) surveyed in 2009, and these data were compared with the data from previous serosurveys. A comparison across different age‐stratified groups using the 2009 data revealed a significant increase in the seropositive rate of anti‐HBc (5.51% vs 12.38%, P=.001) and HBV DNA (1.13% vs 3.96%, P=.007) between those 17‐22 and 23‐24 years of age, possibly due to selective infant immunization in 1984‐1986. Well‐characterized NAr mutants, potential NAr mutants and surface “a” determinant mutants were detected in none, 15 (45.5%) and nine (27.3%) of 33 HBV DNA‐positive subjects, respectively. Of 15 immunized, HBV DNA‐positive young adults (18‐24 years), three (20%) carried “a” determinant mutants. Amongst 1176 HBsAg‐negative subjects evaluated for occult HBV infection, those seropositive for anti‐HBc had a higher seropositive rate for HBV DNA (10/110, 9.1% vs 7/1066, 0.66%; P<.001) and “a” determinant mutants (4/110, 3.6% vs 0/1066; P<.001) than those seronegative for anti‐HBc. Overall, the HBsAg‐positive subjects in six serosurveys showed no significant increase in genotype C frequency in the comparison between the vaccinated and unvaccinated cohorts (25/98, 25.5% versus 14/79, 17.7%, P=.188). Over the 25‐year programme, there was no increase in the prevalence of genotype C in HBsAg carriers and no increase in breakthrough HBV infection or surface mutant prevalence beyond adolescence. Nucleic acid amplification should still be considered the primary screening method for occult hepatitis B detection in high‐risk recipients. |
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| AbstractList | We investigated breakthrough infection and hepatitis B virus (
HBV
) genetic changes in immunized subjects after 25 years of a universal infant immunization. Specifically, serum
HBV DNA
, genotypes, surface antigen mutants and nucleoside analog‐resistant (
NA
r) mutants were assessed in 2853 subjects (<25 years old) surveyed in 2009, and these data were compared with the data from previous serosurveys. A comparison across different age‐stratified groups using the 2009 data revealed a significant increase in the seropositive rate of anti‐
HB
c (5.51% vs 12.38%,
P
=.001) and
HBV DNA
(1.13% vs 3.96%,
P
=.007) between those 17‐22 and 23‐24 years of age, possibly due to selective infant immunization in 1984‐1986. Well‐characterized
NA
r mutants, potential
NA
r mutants and surface “a” determinant mutants were detected in none, 15 (45.5%) and nine (27.3%) of 33
HBV DNA
‐positive subjects, respectively. Of 15 immunized,
HBV DNA
‐positive young adults (18‐24 years), three (20%) carried “a” determinant mutants. Amongst 1176
HB
sAg‐negative subjects evaluated for occult
HBV
infection, those seropositive for anti‐
HB
c had a higher seropositive rate for
HBV DNA
(10/110, 9.1% vs 7/1066, 0.66%;
P
<.001) and “a” determinant mutants (4/110, 3.6% vs 0/1066;
P
<.001) than those seronegative for anti‐
HB
c. Overall, the
HB
sAg‐positive subjects in six serosurveys showed no significant increase in genotype C frequency in the comparison between the vaccinated and unvaccinated cohorts (25/98, 25.5% versus 14/79, 17.7%,
P
=.188). Over the 25‐year programme, there was no increase in the prevalence of genotype C in
HB
sAg carriers and no increase in breakthrough
HBV
infection or surface mutant prevalence beyond adolescence. Nucleic acid amplification should still be considered the primary screening method for occult hepatitis B detection in high‐risk recipients. Summary We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog-resistant (NAr) mutants were assessed in 2853 subjects (<25 years old) surveyed in 2009, and these data were compared with the data from previous serosurveys. A comparison across different age-stratified groups using the 2009 data revealed a significant increase in the seropositive rate of anti-HBc (5.51% vs 12.38%, P=.001) and HBV DNA (1.13% vs 3.96%, P=.007) between those 17-22 and 23-24 years of age, possibly due to selective infant immunization in 1984-1986. Well-characterized NAr mutants, potential NAr mutants and surface "a" determinant mutants were detected in none, 15 (45.5%) and nine (27.3%) of 33 HBV DNA-positive subjects, respectively. Of 15 immunized, HBV DNA-positive young adults (18-24 years), three (20%) carried "a" determinant mutants. Amongst 1176 HBsAg-negative subjects evaluated for occult HBV infection, those seropositive for anti-HBc had a higher seropositive rate for HBV DNA (10/110, 9.1% vs 7/1066, 0.66%; P<.001) and "a" determinant mutants (4/110, 3.6% vs 0/1066; P<.001) than those seronegative for anti-HBc. Overall, the HBsAg-positive subjects in six serosurveys showed no significant increase in genotype C frequency in the comparison between the vaccinated and unvaccinated cohorts (25/98, 25.5% versus 14/79, 17.7%, P=.188). Over the 25-year programme, there was no increase in the prevalence of genotype C in HBsAg carriers and no increase in breakthrough HBV infection or surface mutant prevalence beyond adolescence. Nucleic acid amplification should still be considered the primary screening method for occult hepatitis B detection in high-risk recipients. We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog-resistant (NAr) mutants were assessed in 2853 subjects (<25 years old) surveyed in 2009, and these data were compared with the data from previous serosurveys. A comparison across different age-stratified groups using the 2009 data revealed a significant increase in the seropositive rate of anti-HBc (5.51% vs 12.38%, P=.001) and HBV DNA (1.13% vs 3.96%, P=.007) between those 17-22 and 23-24 years of age, possibly due to selective infant immunization in 1984-1986. Well-characterized NAr mutants, potential NAr mutants and surface "a" determinant mutants were detected in none, 15 (45.5%) and nine (27.3%) of 33 HBV DNA-positive subjects, respectively. Of 15 immunized, HBV DNA-positive young adults (18-24 years), three (20%) carried "a" determinant mutants. Amongst 1176 HBsAg-negative subjects evaluated for occult HBV infection, those seropositive for anti-HBc had a higher seropositive rate for HBV DNA (10/110, 9.1% vs 7/1066, 0.66%; P<.001) and "a" determinant mutants (4/110, 3.6% vs 0/1066; P<.001) than those seronegative for anti-HBc. Overall, the HBsAg-positive subjects in six serosurveys showed no significant increase in genotype C frequency in the comparison between the vaccinated and unvaccinated cohorts (25/98, 25.5% versus 14/79, 17.7%, P=.188). Over the 25-year programme, there was no increase in the prevalence of genotype C in HBsAg carriers and no increase in breakthrough HBV infection or surface mutant prevalence beyond adolescence. Nucleic acid amplification should still be considered the primary screening method for occult hepatitis B detection in high-risk recipients. Summary We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog‐resistant (NAr) mutants were assessed in 2853 subjects (<25 years old) surveyed in 2009, and these data were compared with the data from previous serosurveys. A comparison across different age‐stratified groups using the 2009 data revealed a significant increase in the seropositive rate of anti‐HBc (5.51% vs 12.38%, P=.001) and HBV DNA (1.13% vs 3.96%, P=.007) between those 17‐22 and 23‐24 years of age, possibly due to selective infant immunization in 1984‐1986. Well‐characterized NAr mutants, potential NAr mutants and surface “a” determinant mutants were detected in none, 15 (45.5%) and nine (27.3%) of 33 HBV DNA‐positive subjects, respectively. Of 15 immunized, HBV DNA‐positive young adults (18‐24 years), three (20%) carried “a” determinant mutants. Amongst 1176 HBsAg‐negative subjects evaluated for occult HBV infection, those seropositive for anti‐HBc had a higher seropositive rate for HBV DNA (10/110, 9.1% vs 7/1066, 0.66%; P<.001) and “a” determinant mutants (4/110, 3.6% vs 0/1066; P<.001) than those seronegative for anti‐HBc. Overall, the HBsAg‐positive subjects in six serosurveys showed no significant increase in genotype C frequency in the comparison between the vaccinated and unvaccinated cohorts (25/98, 25.5% versus 14/79, 17.7%, P=.188). Over the 25‐year programme, there was no increase in the prevalence of genotype C in HBsAg carriers and no increase in breakthrough HBV infection or surface mutant prevalence beyond adolescence. Nucleic acid amplification should still be considered the primary screening method for occult hepatitis B detection in high‐risk recipients. We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog-resistant (NAr) mutants were assessed in 2853 subjects (<25 years old) surveyed in 2009, and these data were compared with the data from previous serosurveys. A comparison across different age-stratified groups using the 2009 data revealed a significant increase in the seropositive rate of anti-HBc (5.51% vs 12.38%, P=.001) and HBV DNA (1.13% vs 3.96%, P=.007) between those 17-22 and 23-24 years of age, possibly due to selective infant immunization in 1984-1986. Well-characterized NAr mutants, potential NAr mutants and surface "a" determinant mutants were detected in none, 15 (45.5%) and nine (27.3%) of 33 HBV DNA-positive subjects, respectively. Of 15 immunized, HBV DNA-positive young adults (18-24 years), three (20%) carried "a" determinant mutants. Amongst 1176 HBsAg-negative subjects evaluated for occult HBV infection, those seropositive for anti-HBc had a higher seropositive rate for HBV DNA (10/110, 9.1% vs 7/1066, 0.66%; P<.001) and "a" determinant mutants (4/110, 3.6% vs 0/1066; P<.001) than those seronegative for anti-HBc. Overall, the HBsAg-positive subjects in six serosurveys showed no significant increase in genotype C frequency in the comparison between the vaccinated and unvaccinated cohorts (25/98, 25.5% versus 14/79, 17.7%, P=.188). Over the 25-year programme, there was no increase in the prevalence of genotype C in HBsAg carriers and no increase in breakthrough HBV infection or surface mutant prevalence beyond adolescence. Nucleic acid amplification should still be considered the primary screening method for occult hepatitis B detection in high-risk recipients.We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog-resistant (NAr) mutants were assessed in 2853 subjects (<25 years old) surveyed in 2009, and these data were compared with the data from previous serosurveys. A comparison across different age-stratified groups using the 2009 data revealed a significant increase in the seropositive rate of anti-HBc (5.51% vs 12.38%, P=.001) and HBV DNA (1.13% vs 3.96%, P=.007) between those 17-22 and 23-24 years of age, possibly due to selective infant immunization in 1984-1986. Well-characterized NAr mutants, potential NAr mutants and surface "a" determinant mutants were detected in none, 15 (45.5%) and nine (27.3%) of 33 HBV DNA-positive subjects, respectively. Of 15 immunized, HBV DNA-positive young adults (18-24 years), three (20%) carried "a" determinant mutants. Amongst 1176 HBsAg-negative subjects evaluated for occult HBV infection, those seropositive for anti-HBc had a higher seropositive rate for HBV DNA (10/110, 9.1% vs 7/1066, 0.66%; P<.001) and "a" determinant mutants (4/110, 3.6% vs 0/1066; P<.001) than those seronegative for anti-HBc. Overall, the HBsAg-positive subjects in six serosurveys showed no significant increase in genotype C frequency in the comparison between the vaccinated and unvaccinated cohorts (25/98, 25.5% versus 14/79, 17.7%, P=.188). Over the 25-year programme, there was no increase in the prevalence of genotype C in HBsAg carriers and no increase in breakthrough HBV infection or surface mutant prevalence beyond adolescence. Nucleic acid amplification should still be considered the primary screening method for occult hepatitis B detection in high-risk recipients. |
| Author | Hsu, H.‐Y. Chen, D.‐S. Ni, Y.‐H. Chen, P.‐J. Chen, H.‐L. Wu, J.‐F. Chang, M.‐H. Chiang, C.‐L. |
| Author_xml | – sequence: 1 givenname: H.‐Y. surname: Hsu fullname: Hsu, H.‐Y. organization: National Taiwan University – sequence: 2 givenname: M.‐H. orcidid: 0000-0002-3648-9261 surname: Chang fullname: Chang, M.‐H. email: changmh@ntu.edu.tw organization: National Taiwan University – sequence: 3 givenname: Y.‐H. surname: Ni fullname: Ni, Y.‐H. organization: National Taiwan University – sequence: 4 givenname: C.‐L. surname: Chiang fullname: Chiang, C.‐L. organization: National Taiwan University – sequence: 5 givenname: J.‐F. surname: Wu fullname: Wu, J.‐F. organization: National Taiwan University – sequence: 6 givenname: H.‐L. surname: Chen fullname: Chen, H.‐L. organization: National Taiwan University – sequence: 7 givenname: P.‐J. surname: Chen fullname: Chen, P.‐J. organization: National Taiwan University – sequence: 8 givenname: D.‐S. surname: Chen fullname: Chen, D.‐S. organization: National Taiwan University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28182307$$D View this record in MEDLINE/PubMed |
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| Copyright | 2017 John Wiley & Sons Ltd 2017 John Wiley & Sons Ltd. Copyright © 2017 John Wiley & Sons Ltd |
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| Keywords | HBV DNA occult HBV infection surface antigen mutants nucleoside analog-resistant (NAr) mutants genotype vaccination |
| Language | English |
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| Notes | Funding information This work was supported by Grant NSC 102‐2628‐B‐002‐026‐MY3 from National Science Council, Taiwan, by Grant MOST 105‐2314‐B‐002‐144 from Ministry of Science and Technology, Taiwan, and by the Liver Disease Prevention and Treatment Research Foundation, Taiwan ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant... We investigated breakthrough infection and hepatitis B virus ( HBV ) genetic changes in immunized subjects after 25 years of a universal infant immunization.... We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization.... Summary We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant... We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25 years of a universal infant immunization.... |
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| SubjectTerms | Adolescent Adolescents Age Antigens Child Child, Preschool Deoxyribonucleic acid DNA DNA, Viral - analysis DNA, Viral - genetics Female genotype Genotypes HBV DNA Hepatitis Hepatitis B Hepatitis B surface antigen Hepatitis B Surface Antigens - genetics Hepatitis B Vaccines - administration & dosage Hepatitis B virus - classification Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - virology Humans Immunization Infant Infections Interferon Male Mutant Proteins - genetics Nucleic acids Nucleoside analogs nucleoside analog‐resistant (NAr) mutants occult HBV infection RNA-directed DNA polymerase RNA-Directed DNA Polymerase - genetics Serum - virology surface antigen mutants Taiwan - epidemiology Time Factors Vaccination Young Adult |
| Title | Chronologic changes in serum hepatitis B virus DNA, genotypes, surface antigen mutants and reverse transcriptase mutants during 25‐year nationwide immunization in Taiwan |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjvh.12687 https://www.ncbi.nlm.nih.gov/pubmed/28182307 https://www.proquest.com/docview/1922408862 https://www.proquest.com/docview/1866695852 |
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