Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population

• Published in: Diabetes, obesity & metabolism Vol. 25; no. 10; pp. 2928 - 2936
• Main Authors: Liao, Wen‐Ling, Huang, Yu‐Nan, Chang, Ya‐Wen, Liu, Ting‐Yuan, Lu, Hsing‐Fang, Tiao, Zih‐Yu, Su, Pen‐Hua, Wang, Chung‐Hsing, Tsai, Fuu‐Jen
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2023; Wiley Subscription Services, Inc
• Subjects: Age; Antigens; clinical event; Diabetes; Diabetes mellitus (insulin dependent); Diagnosis; DQA1 protein; electronic medical record; Electronic medical records; Genetic analysis; Genomes; genome‐wide association studies; Histocompatibility antigen HLA; human leukocyte antigen; Ketoacidosis; Leukocytes; Medical screening; polygenic risk scores; Population studies; Risk assessment; Risk factors; type 1 diabetes; electronic medical record; type 1 diabetes; clinical event; human leukocyte antigen; genome-wide association studies; polygenic risk scores

Aims To analyse the genome‐wide association study (GWAS) data of patients with type 1 diabetes mellitus (T1D) in order to develop a risk score for the genetic effects on T1D risk and age at diagnosis in the Taiwanese population. Materials and Methods We selected 610 patients with T1D and 2511 health...