Predominant polarity and hippocampal subfield volumes in Bipolar disorders
Objectives Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the...
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| Published in | Bipolar disorders Vol. 22; no. 5; pp. 490 - 497 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Denmark
Wiley Subscription Services, Inc
01.08.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1398-5647 1399-5618 1399-5618 |
| DOI | 10.1111/bdi.12857 |
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| Abstract | Objectives
Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the hypothesis that patients with BD differ in hippocampal subfield volumes according to their PP.
Methods
We assessed 172 outpatients, diagnosed with BD according to DSM‐IV‐TR criteria, and 150 healthy control (HC) participants. High‐resolution magnetic resonance imaging was performed on all subjects and volumes of all hippocampal subfields were measured using FreeSurfer.
Results
Patients with depressive PP (BD‐DP) and with uncertain PP (BD‐UP) but not with manic/hypomanic PP (BD‐MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. When directly compared, BD‐DP presented with smaller bilateral presubiculum/subiculum volumes than BD‐MP.
Conclusions
Results support the potential utility of PP not only as a clinical but also as a neurobiological specifier of BD. |
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| AbstractList | Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the hypothesis that patients with BD differ in hippocampal subfield volumes according to their PP.OBJECTIVESPredominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the hypothesis that patients with BD differ in hippocampal subfield volumes according to their PP.We assessed 172 outpatients, diagnosed with BD according to DSM-IV-TR criteria, and 150 healthy control (HC) participants. High-resolution magnetic resonance imaging was performed on all subjects and volumes of all hippocampal subfields were measured using FreeSurfer.METHODSWe assessed 172 outpatients, diagnosed with BD according to DSM-IV-TR criteria, and 150 healthy control (HC) participants. High-resolution magnetic resonance imaging was performed on all subjects and volumes of all hippocampal subfields were measured using FreeSurfer.Patients with depressive PP (BD-DP) and with uncertain PP (BD-UP) but not with manic/hypomanic PP (BD-MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. When directly compared, BD-DP presented with smaller bilateral presubiculum/subiculum volumes than BD-MP.RESULTSPatients with depressive PP (BD-DP) and with uncertain PP (BD-UP) but not with manic/hypomanic PP (BD-MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. When directly compared, BD-DP presented with smaller bilateral presubiculum/subiculum volumes than BD-MP.Results support the potential utility of PP not only as a clinical but also as a neurobiological specifier of BD.CONCLUSIONSResults support the potential utility of PP not only as a clinical but also as a neurobiological specifier of BD. Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the hypothesis that patients with BD differ in hippocampal subfield volumes according to their PP. We assessed 172 outpatients, diagnosed with BD according to DSM-IV-TR criteria, and 150 healthy control (HC) participants. High-resolution magnetic resonance imaging was performed on all subjects and volumes of all hippocampal subfields were measured using FreeSurfer. Patients with depressive PP (BD-DP) and with uncertain PP (BD-UP) but not with manic/hypomanic PP (BD-MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. When directly compared, BD-DP presented with smaller bilateral presubiculum/subiculum volumes than BD-MP. Results support the potential utility of PP not only as a clinical but also as a neurobiological specifier of BD. Objectives Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the hypothesis that patients with BD differ in hippocampal subfield volumes according to their PP. Methods We assessed 172 outpatients, diagnosed with BD according to DSM‐IV‐TR criteria, and 150 healthy control (HC) participants. High‐resolution magnetic resonance imaging was performed on all subjects and volumes of all hippocampal subfields were measured using FreeSurfer. Results Patients with depressive PP (BD‐DP) and with uncertain PP (BD‐UP) but not with manic/hypomanic PP (BD‐MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. When directly compared, BD‐DP presented with smaller bilateral presubiculum/subiculum volumes than BD‐MP. Conclusions Results support the potential utility of PP not only as a clinical but also as a neurobiological specifier of BD. ObjectivesPredominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the hypothesis that patients with BD differ in hippocampal subfield volumes according to their PP.MethodsWe assessed 172 outpatients, diagnosed with BD according to DSM‐IV‐TR criteria, and 150 healthy control (HC) participants. High‐resolution magnetic resonance imaging was performed on all subjects and volumes of all hippocampal subfields were measured using FreeSurfer.ResultsPatients with depressive PP (BD‐DP) and with uncertain PP (BD‐UP) but not with manic/hypomanic PP (BD‐MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. When directly compared, BD‐DP presented with smaller bilateral presubiculum/subiculum volumes than BD‐MP.ConclusionsResults support the potential utility of PP not only as a clinical but also as a neurobiological specifier of BD. |
| Author | Simonetti, Alessio Ciullo, Valentina Sani, Gabriele Piras, Fabrizio Janiri, Delfina Spalletta, Gianfranco |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31630469$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neuroimage.2004.03.037 10.1016/j.jad.2018.12.093 10.1111/adb.12015 10.1038/nrn2614 10.2174/1570159X14666160708231216 10.1016/j.jad.2014.03.035 10.1016/j.physbeh.2009.09.008 10.1176/appi.books.9780890423349 10.1109/TMI.2010.2050897 10.1111/acps.12179 10.1111/j.2044-8341.1959.tb00467.x 10.1080/87565649109540545 10.1007/978-1-4939-7647-8_20 10.1192/bjp.133.5.429 10.1016/j.jad.2018.11.051 10.1016/j.neuroimage.2004.07.016 10.1097/YCO.0000000000000122 10.1111/acps.12140 10.1016/j.jad.2009.03.016 10.1073/pnas.81.19.6174 10.1016/j.bbr.2006.05.035 10.1111/j.1600-0447.2011.01818.x 10.1001/jamapsychiatry.2014.453 10.1016/j.biopsych.2014.06.020 10.1016/S0140-6736(13)61611-6 10.1038/mp.2015.69 10.1097/00005053-192104000-00057 10.1159/000358808 10.1177/0004867419827649 10.1016/j.jad.2019.04.071 10.1016/S0896-6273(02)00569-X 10.1016/j.jad.2007.07.021 10.1016/j.neuroimage.2004.03.032 10.1016/j.jad.2009.11.005 10.1038/mp.2015.227 10.1016/j.jad.2006.01.032 10.2174/1570159X14666160607101400 10.1016/j.neulet.2017.06.058 10.1111/bdi.12516 10.1016/0022-3956(75)90026-6 10.1177/0004867418824021 10.1016/j.phrs.2016.11.029 10.1016/j.bbr.2006.05.036 10.1002/hipo.20615 10.1016/j.jad.2014.03.054 10.1038/mp.2016.262 10.1001/archgenpsychiatry.2010.15 |
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| References | 2004; 22 2010; 99 1993; 9 2004; 29 2019; 53 2015; 77 2004; 23 2006; 174 1975; 12 2014; 26 2008; 107 2019; 245 1978; 133 2019; 246 2012; 125 2009; 119 2017; 117 2014; 129 2010; 67 2009; 10 2000 2010; 29 2015; 219 2014; 19 2009; 19 2014; 163 2014; 164 1959; 32 2006; 93 1984; 81 2017; 2018 2017; 22 2010; 124 2002; 33 1997 2013; 382 2002 2014; 83 2017; 655 2009; 34 2015; 28 2017; 15 1960; 23 1921 2016; 21 2018 2017 2017; 19 2014 2014; 71 2019; 253 e_1_2_8_28_1 e_1_2_8_24_1 e_1_2_8_49_1 e_1_2_8_3_1 e_1_2_8_5_1 Rapinesi C (e_1_2_8_56_1) 2014; 26 e_1_2_8_7_1 e_1_2_8_9_1 e_1_2_8_20_1 First M (e_1_2_8_22_1) 2002 e_1_2_8_43_1 Aggleton JP (e_1_2_8_47_1) 2015 e_1_2_8_45_1 e_1_2_8_41_1 e_1_2_8_17_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_15_1 e_1_2_8_38_1 First M (e_1_2_8_26_1) 1997 e_1_2_8_32_1 e_1_2_8_55_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_53_1 e_1_2_8_51_1 e_1_2_8_30_1 Mckinnon MC (e_1_2_8_19_1) 2009; 34 e_1_2_8_29_1 e_1_2_8_46_1 e_1_2_8_27_1 e_1_2_8_48_1 e_1_2_8_2_1 First M (e_1_2_8_25_1) 2002 e_1_2_8_4_1 e_1_2_8_6_1 e_1_2_8_8_1 e_1_2_8_21_1 e_1_2_8_42_1 Sani G (e_1_2_8_57_1) 2017; 2018 e_1_2_8_23_1 e_1_2_8_44_1 e_1_2_8_40_1 e_1_2_8_18_1 e_1_2_8_39_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_16_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_12_1 e_1_2_8_33_1 Campbell S (e_1_2_8_37_1) 2004; 29 e_1_2_8_54_1 e_1_2_8_52_1 e_1_2_8_50_1 |
| References_xml | – volume: 23 start-page: 56 year: 1960 end-page: 62 article-title: A rating scale for depression publication-title: J Neurol Neurosurg Psychiatry – volume: 26 start-page: 281 issue: 3 year: 2014 end-page: 284 article-title: Alcohol and suicidality: could deep transcranial magnetic stimulation (DTMS) be a possible treatment? publication-title: Psychiatr Danub – volume: 21 start-page: 806 issue: 6 year: 2016 end-page: 812 article-title: Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group publication-title: Mol Psychiatry – volume: 246 start-page: 806 issue: December 2018 year: 2019 end-page: 813 article-title: Predominant polarity in bipolar I and II disorders: a five‐year follow‐up study publication-title: J Affect Disord – volume: 93 start-page: 13 year: 2006 end-page: 17 article-title: Clinical and therapeutic implications of predominant polarity in bipolar disorder publication-title: J Affect Disord – volume: 83 start-page: 213 year: 2014 end-page: 221 article-title: Mixed depression: clinical features and predictors of its onset associated with antidepressant use publication-title: Psychother Psychosom – volume: 174 start-page: 225 year: 2006 end-page: 231 article-title: A role for the subiculum in the brain motivation/reward circuitry publication-title: Behav Brain Res – volume: 164 start-page: 14 year: 2014 end-page: 18 article-title: Koukopoulos’ diagnostic criteria for mixed depression: a validation study. publication-title: J Affect Disord – volume: 133 start-page: 429 year: 1978 end-page: 435 article-title: A rating scale for mania: reliability, validity and sensitivity publication-title: Br J Psychiatry – volume: 99 start-page: 186 issue: 2 year: 2010 end-page: 193 article-title: The effects of chronic glucocorticoid exposure on dendritic length, synapse numbers and glial volume in animal models: implications for hippocampal volume reductions in depression publication-title: Physiol Behav – start-page: 339 year: 2017 end-page: 352 article-title: Neurobiological evidence for the primacy of mania hypothesis. publication-title: Curr Neuropharmacol – start-page: 339 year: 2018 end-page: 383 – volume: 28 start-page: 7 issue: 1 year: 2015 end-page: 12 article-title: Reward processing dysfunction in major depression, bipolar disorder and schizophrenia publication-title: Curr Opin Psychiatry – volume: 22 start-page: 1060 issue: 3 year: 2004 end-page: 1075 article-title: A hybrid approach to the skill stripping problem in MRI publication-title: NeuroImage – volume: 32 start-page: 50 year: 1959 end-page: 55 article-title: The assessment of anxiety states by rating publication-title: Br J Med Psychol – volume: 67 start-page: 339 issue: 4 year: 2010 end-page: 347 article-title: Longitudinal course of bipolar I disorder: duration of mood episodes publication-title: Arch Gen Psychiatry – volume: 245 start-page: 279 issue: October 2018 year: 2019 end-page: 282 article-title: Predominant polarity classification and associated clinical variables in bipolar disorder: a machine learning approach publication-title: J Affect Disord – volume: 15 start-page: 409 issue: 3 year: 2017 end-page: 416 article-title: Who’s the leader, mania or depression? Predominant polarity and alcohol/polysubstance use in bipolar disorders publication-title: Curr Neuropharmacol – volume: 9 start-page: 77 year: 1993 end-page: 85 article-title: The mini‐mental state examination: Normative study of an Italian random sample publication-title: Dev Neuropsychol – volume: 174 start-page: 215 year: 2006 end-page: 224 article-title: Role of the ventral subiculum in stress integration publication-title: Behav Brain Res – volume: 163 start-page: 56 year: 2014 end-page: 64 article-title: Predominant polarity as a course specifier for bipolar disorder: a systematic review publication-title: J Affect Disord – volume: 22 start-page: 1732 year: 2004 end-page: 1743 article-title: Correction for intracranial volume in analysis of whole brain atrophy in multiple sclerosis: the proportion vs. residual method publication-title: NeuroImage – volume: 23 start-page: S69 issue: Suppl. 1 year: 2004 end-page: 84 article-title: Sequence‐independent segmentation of magnetic resonance images publication-title: NeuroImage – year: 1997 – volume: 71 start-page: 769 issue: 7 year: 2014 end-page: 777 article-title: Medial temporal lobe structures and hippocampal subfields in psychotic disorders: findings from the bipolar‐schizophrenia network on intermediate phenotypes (B‐SNIP) study publication-title: JAMA Psychiatry – volume: 129 start-page: 366 year: 2014 end-page: 374 article-title: Clinical implications of predominant polarity and the polarity index in bipolar disorder: a naturalistic study publication-title: Acta Psychiatr Scand – volume: 117 start-page: 46 year: 2017 end-page: 53 article-title: Paradoxical sleep deprivation in rats causes a selective reduction in the expression of type‐2 metabotropic glutamate receptors in the hippocampus publication-title: Pharmacol Res – volume: 10 start-page: 272 issue: 4 year: 2009 end-page: 282 article-title: The anatomy of memory: an interactive overview of the parahippocampal‐hippocampal network publication-title: Nat Rev. Neurosci – volume: 34 start-page: 41 issue: 1 year: 2009 end-page: 54 article-title: A meta‐analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder publication-title: J Psychiatry Neurosci – volume: 107 start-page: 45 year: 2008 end-page: 51 article-title: Predominant polarity in bipolar disorder: diagnostic implications publication-title: J Affect Disord – volume: 19 start-page: 338 issue: 3 year: 2014 end-page: 342 article-title: Role of ventral subiculum in context‐induced reinstatement of heroin seeking in rats publication-title: Addict Biol – volume: 219 start-page: 65 year: 2015 end-page: 82 – volume: 19 start-page: 549 issue: 6 year: 2009 end-page: 557 article-title: Automated segmentation of hippocampal subfields from ultra‐high resolution in vivo MRI publication-title: Hippocampus – volume: 53 start-page: 447 issue: 5 year: 2019 end-page: 457 article-title: The effects of childhood trauma on adolescent hippocampal subfields publication-title: Aust N Z J Psychiatry – volume: 53 start-page: 316 issue: 4 year: 2019 end-page: 325 article-title: Effect of stress gene‐by‐environment interactions on hippocampal volumes and cortisol secretion in adolescent girls publication-title: Aust N Z J Psychiatry – volume: 125 start-page: 293 issue: 4 year: 2012 end-page: 302 article-title: Predominant recurrence polarity among 928 adult international bipolar I disorder patients publication-title: Acta Psychiatr Scand – year: 2000 – volume: 655 start-page: 68 year: 2017 end-page: 75 article-title: Neural functional correlates of empathic face processing publication-title: Neurosci Lett – year: 1921 – volume: 81 start-page: 6174 issue: 19 year: 1984 end-page: 6177 article-title: Glucocorticoid‐sensitive hippocampal neurons are involved in terminating the adrenocortical stress response publication-title: Proc Natl Acad Sci USA – volume: 124 start-page: 250 year: 2010 end-page: 255 article-title: Different profile of substance abuse in relation to predominant polarity in bipolar disorder: the Vitoria long‐term follow‐up study publication-title: J Affect Disord – volume: 22 start-page: 1352 issue: 9 year: 2017 end-page: 1358 article-title: Hippocampal subfield volumes in mood disorders publication-title: Mol Psychiatry – volume: 77 start-page: 581 issue: 6 year: 2015 end-page: 588 article-title: In vivo hippocampal subfield volumes in schizophrenia and bipolar disorder publication-title: Biol Psychiatry – volume: 33 start-page: 341 issue: 3 year: 2002 end-page: 355 article-title: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain publication-title: Neuron – volume: 382 start-page: 1575 issue: 9904 year: 2013 end-page: 1586 article-title: Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010 publication-title: Lancet – volume: 119 start-page: 28 year: 2009 end-page: 33 article-title: Predominant polarity and temperament in bipolar and unipolar affective disorders publication-title: J Affect Disord – start-page: 4 year: 2014 end-page: 16 article-title: Clinical overview DSM‐5 criteria for depression with mixed features: a farewell to mixed depression publication-title: Acta Psychiatr Scand – volume: 12 start-page: 189 year: 1975 end-page: 198 article-title: “Mini‐mental state”. A practical method for grading the cognitive state of patients for the clinician publication-title: J Psychiatr Res – volume: 253 start-page: 35 issue: January year: 2019 end-page: 43 article-title: Hippocampal subfield volumes and childhood trauma in bipolar disorders publication-title: J Affect Disord – volume: 19 start-page: 353 issue: 5 year: 2017 end-page: 362 article-title: Amygdala and hippocampus volumes are differently affected by childhood trauma in patients with bipolar disorders and healthy controls publication-title: Bipolar Disord – volume: 2018 start-page: 341 issue: 232 year: 2017 end-page: 348 article-title: Association between duration of lithium exposure and hippocampus/amygdala volumes in type I bipolar disorder publication-title: J Affect Disord – year: 2002 – volume: 29 start-page: 1714 issue: 10 year: 2010 end-page: 1729 article-title: A generative model for image segmentation based on label fusion publication-title: IEEE Trans Med Imaging – volume: 29 start-page: 417 issue: 6 year: 2004 end-page: 426 article-title: The role of the hippocampus in the pathophysiology of major depression publication-title: J Psychiatry Neurosci – volume: 21 start-page: 1710 issue: 12 year: 2016 end-page: 1716 article-title: Subcortical volumetric abnormalities in bipolar disorder publication-title: Mol Psychiatry – ident: e_1_2_8_36_1 doi: 10.1016/j.neuroimage.2004.03.037 – volume: 34 start-page: 41 issue: 1 year: 2009 ident: e_1_2_8_19_1 article-title: A meta‐analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder publication-title: J Psychiatry Neurosci – ident: e_1_2_8_52_1 doi: 10.1016/j.jad.2018.12.093 – volume: 2018 start-page: 341 issue: 232 year: 2017 ident: e_1_2_8_57_1 article-title: Association between duration of lithium exposure and hippocampus/amygdala volumes in type I bipolar disorder publication-title: J Affect Disord – ident: e_1_2_8_48_1 doi: 10.1111/adb.12015 – ident: e_1_2_8_46_1 doi: 10.1038/nrn2614 – volume-title: Structured Clinical Interview for DSM‐IV‐TR Axis I Disorders, Research Version, Patient Edition. (SCID‐I/P) year: 2002 ident: e_1_2_8_22_1 – ident: e_1_2_8_50_1 doi: 10.2174/1570159X14666160708231216 – ident: e_1_2_8_5_1 doi: 10.1016/j.jad.2014.03.035 – ident: e_1_2_8_39_1 doi: 10.1016/j.physbeh.2009.09.008 – ident: e_1_2_8_21_1 doi: 10.1176/appi.books.9780890423349 – volume-title: Structured Clinical Interview for DSM‐IV‐TR Axis I Disorders, Research Version, Non‐Patient Edition. (SCID‐I/NP) year: 2002 ident: e_1_2_8_25_1 – ident: e_1_2_8_34_1 doi: 10.1109/TMI.2010.2050897 – volume: 26 start-page: 281 issue: 3 year: 2014 ident: e_1_2_8_56_1 article-title: Alcohol and suicidality: could deep transcranial magnetic stimulation (DTMS) be a possible treatment? publication-title: Psychiatr Danub – ident: e_1_2_8_9_1 doi: 10.1111/acps.12179 – start-page: 65 volume-title: Progress in Brain Research year: 2015 ident: e_1_2_8_47_1 – ident: e_1_2_8_29_1 doi: 10.1111/j.2044-8341.1959.tb00467.x – ident: e_1_2_8_24_1 doi: 10.1080/87565649109540545 – ident: e_1_2_8_17_1 doi: 10.1007/978-1-4939-7647-8_20 – ident: e_1_2_8_27_1 doi: 10.1192/bjp.133.5.429 – ident: e_1_2_8_11_1 doi: 10.1016/j.jad.2018.11.051 – ident: e_1_2_8_33_1 doi: 10.1016/j.neuroimage.2004.07.016 – ident: e_1_2_8_49_1 doi: 10.1097/YCO.0000000000000122 – ident: e_1_2_8_54_1 doi: 10.1111/acps.12140 – ident: e_1_2_8_12_1 doi: 10.1016/j.jad.2009.03.016 – ident: e_1_2_8_38_1 doi: 10.1073/pnas.81.19.6174 – ident: e_1_2_8_40_1 doi: 10.1016/j.bbr.2006.05.035 – ident: e_1_2_8_8_1 doi: 10.1111/j.1600-0447.2011.01818.x – ident: e_1_2_8_15_1 doi: 10.1001/jamapsychiatry.2014.453 – ident: e_1_2_8_16_1 doi: 10.1016/j.biopsych.2014.06.020 – ident: e_1_2_8_2_1 doi: 10.1016/S0140-6736(13)61611-6 – ident: e_1_2_8_20_1 doi: 10.1038/mp.2015.69 – volume-title: Structured Clinical Interview for DSM‐IV Axis II Personality Disorders, (SCID‐II) year: 1997 ident: e_1_2_8_26_1 – ident: e_1_2_8_3_1 doi: 10.1097/00005053-192104000-00057 – volume: 29 start-page: 417 issue: 6 year: 2004 ident: e_1_2_8_37_1 article-title: The role of the hippocampus in the pathophysiology of major depression publication-title: J Psychiatry Neurosci – ident: e_1_2_8_30_1 doi: 10.1159/000358808 – ident: e_1_2_8_44_1 doi: 10.1177/0004867419827649 – ident: e_1_2_8_18_1 doi: 10.1016/j.jad.2019.04.071 – ident: e_1_2_8_32_1 doi: 10.1016/S0896-6273(02)00569-X – ident: e_1_2_8_6_1 doi: 10.1016/j.jad.2007.07.021 – ident: e_1_2_8_31_1 doi: 10.1016/j.neuroimage.2004.03.032 – ident: e_1_2_8_7_1 doi: 10.1016/j.jad.2009.11.005 – ident: e_1_2_8_13_1 doi: 10.1038/mp.2015.227 – ident: e_1_2_8_4_1 doi: 10.1016/j.jad.2006.01.032 – ident: e_1_2_8_10_1 doi: 10.2174/1570159X14666160607101400 – ident: e_1_2_8_43_1 doi: 10.1016/j.neulet.2017.06.058 – ident: e_1_2_8_14_1 doi: 10.1111/bdi.12516 – ident: e_1_2_8_28_1 doi: 10.1111/j.2044-8341.1959.tb00467.x – ident: e_1_2_8_23_1 doi: 10.1016/0022-3956(75)90026-6 – ident: e_1_2_8_45_1 doi: 10.1177/0004867418824021 – ident: e_1_2_8_42_1 doi: 10.1016/j.phrs.2016.11.029 – ident: e_1_2_8_41_1 doi: 10.1016/j.bbr.2006.05.036 – ident: e_1_2_8_35_1 doi: 10.1002/hipo.20615 – ident: e_1_2_8_53_1 doi: 10.1016/j.jad.2014.03.054 – ident: e_1_2_8_51_1 doi: 10.1038/mp.2016.262 – ident: e_1_2_8_55_1 doi: 10.1001/archgenpsychiatry.2010.15 |
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Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield... Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric... ObjectivesPredominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield... |
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| SubjectTerms | Bipolar disorder Bipolar Disorder - diagnostic imaging bipolar disorders depression Diagnostic and Statistical Manual of Mental Disorders hippocampal subfields Hippocampus Hippocampus - diagnostic imaging Humans magnetic resonance Magnetic Resonance Imaging mania Mood Neurobiology neuroimaging Polarity predominant polarity Presubiculum Subiculum |
| Title | Predominant polarity and hippocampal subfield volumes in Bipolar disorders |
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