Maslinic acid prevents IL‐1β‐induced inflammatory response in osteoarthritis via PI3K/AKT/NF‐κB pathways

• Published in: Journal of cellular physiology Vol. 236; no. 3; pp. 1939 - 1949
• Main Authors: Chen, Yan‐Lin, Yan, De‐Yi, Wu, Chen‐Yu, Xuan, Jiang‐Wei, Jin, Chen‐Qiang, Hu, Xin‐Li, Bao, Guo‐Dong, Bian, Yu‐Jie, Hu, Zhi‐Chao, Shen, Zhong‐Hai, Ni, Wen‐Fei
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2021
• Subjects: 1-Phosphatidylinositol 3-kinase; Aged; AKT protein; Animals; Arthritis; Biomedical materials; Cartilage; Cartilage (articular); Cartilage diseases; Cell Survival - drug effects; Chondrocytes; Chondrocytes - drug effects; Chondrocytes - metabolism; Chondrocytes - pathology; Collagenase 3; Cyclooxygenase 2 - metabolism; Dinoprostone - metabolism; Disease Models, Animal; Extracellular matrix; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Female; Humans; Inflammation; Inflammation - complications; Inflammation - prevention & control; Inflammatory response; Interleukin-1beta - adverse effects; Interleukin-6 - metabolism; Interleukins; Joint diseases; Male; maslinic acid; Matrix metalloproteinase; Matrix metalloproteinases; Mice; Mice, Inbred C57BL; Models, Biological; NF-kappa B - metabolism; NF-KappaB Inhibitor alpha - metabolism; Nitric oxide; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; Nitric-oxide synthase; Osteoarthritis; Osteoarthritis - drug therapy; Osteoarthritis - metabolism; Pathogenesis; Phosphatidylinositol 3-Kinases - metabolism; PI3K/Akt/NF‐κB; Prostaglandin E2; Prostaglandin endoperoxide synthase; Protein Transport - drug effects; Proteolysis - drug effects; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; Thrombospondin; Transcription Factor RelA - metabolism; Triterpenes - chemistry; Triterpenes - pharmacology; Triterpenes - therapeutic use; Tumor necrosis factor; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; PI3K/Akt/NF-κB; osteoarthritis; maslinic acid

Osteoarthritis (OA) is a degenerative joint disease characterized by destruction of articular cartilage. The inflammatory response is the most important factor affecting the disease process. As interleukin‐1β (IL‐1β) stimulates several key mediators in the inflammatory response, it plays a major rol...