Effect of oral isotretinoin on the nucleo‐cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris
Oral isotretinoin is the most effective anti‐acne drug with the strongest sebum‐suppressive effect caused by sebocyte apoptosis. It has been hypothesized that upregulation of nuclear FoxO transcription factors and p53 mediate isotretinoin‐induced sebocyte apoptosis in vivo. It is the aim of our stud...
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| Published in | Experimental dermatology Vol. 27; no. 12; pp. 1344 - 1351 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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01.12.2018
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| Abstract | Oral isotretinoin is the most effective anti‐acne drug with the strongest sebum‐suppressive effect caused by sebocyte apoptosis. It has been hypothesized that upregulation of nuclear FoxO transcription factors and p53 mediate isotretinoin‐induced sebocyte apoptosis in vivo. It is the aim of our study to analyse the distribution of the pro‐apoptotic transcription factors FoxO1 and FoxO3 in the nuclear and cytoplasmic compartments of human sebocytes in vivo before and during isotretinoin treatment of acne patients. Immunohistochemical analysis of skin biopsies with antibodies distinguishing phosphorylated and non‐phosphorylated human FoxO1 and FoxO3 proteins was performed before isotretinoin treatment, six weeks after initiation of isotretinoin therapy, and in acne‐free control patients not treated with isotretinoin. Our in vivo study demonstrates a significant increase in the nucleo‐cytoplasmic ratio of non‐phosphorylated FoxO1 and FoxO3 during isotretinoin treatment of acne patients. Translational and presented experimental evidence indicates that upregulation of nuclear FoxO1 and FoxO3 proteins is involved in isotretinoin‐induced pro‐apoptotic signalling in sebocytes confirming the scientific hypothesis of isotretinoin‐mediated upregulation of FoxO expression. |
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| AbstractList | Oral isotretinoin is the most effective anti‐acne drug with the strongest sebum‐suppressive effect caused by sebocyte apoptosis. It has been hypothesized that upregulation of nuclear FoxO transcription factors and p53 mediate isotretinoin‐induced sebocyte apoptosis in vivo. It is the aim of our study to analyse the distribution of the pro‐apoptotic transcription factors FoxO1 and FoxO3 in the nuclear and cytoplasmic compartments of human sebocytes in vivo before and during isotretinoin treatment of acne patients. Immunohistochemical analysis of skin biopsies with antibodies distinguishing phosphorylated and non‐phosphorylated human FoxO1 and FoxO3 proteins was performed before isotretinoin treatment, six weeks after initiation of isotretinoin therapy, and in acne‐free control patients not treated with isotretinoin. Our in vivo study demonstrates a significant increase in the nucleo‐cytoplasmic ratio of non‐phosphorylated FoxO1 and FoxO3 during isotretinoin treatment of acne patients. Translational and presented experimental evidence indicates that upregulation of nuclear FoxO1 and FoxO3 proteins is involved in isotretinoin‐induced pro‐apoptotic signalling in sebocytes confirming the scientific hypothesis of isotretinoin‐mediated upregulation of FoxO expression. Abstract Oral isotretinoin is the most effective anti‐acne drug with the strongest sebum‐suppressive effect caused by sebocyte apoptosis. It has been hypothesized that upregulation of nuclear FoxO transcription factors and p53 mediate isotretinoin‐induced sebocyte apoptosis in vivo. It is the aim of our study to analyse the distribution of the pro‐apoptotic transcription factors FoxO1 and FoxO3 in the nuclear and cytoplasmic compartments of human sebocytes in vivo before and during isotretinoin treatment of acne patients. Immunohistochemical analysis of skin biopsies with antibodies distinguishing phosphorylated and non‐phosphorylated human FoxO1 and FoxO3 proteins was performed before isotretinoin treatment, six weeks after initiation of isotretinoin therapy, and in acne‐free control patients not treated with isotretinoin. Our in vivo study demonstrates a significant increase in the nucleo‐cytoplasmic ratio of non‐phosphorylated FoxO1 and FoxO3 during isotretinoin treatment of acne patients. Translational and presented experimental evidence indicates that upregulation of nuclear FoxO1 and FoxO3 proteins is involved in isotretinoin‐induced pro‐apoptotic signalling in sebocytes confirming the scientific hypothesis of isotretinoin‐mediated upregulation of FoxO expression. |
| Author | Roshdy, Osama Hussein Talaat, Iman Mamdouh Zaki, Eiman Ibrahim Abdalla, Dina Mohamed Abdelmaksoud, Rania ElSaied Agamia, Naglaa Fathi El Tawdy, Amira Melnik, Bodo C. |
| Author_xml | – sequence: 1 givenname: Naglaa Fathi surname: Agamia fullname: Agamia, Naglaa Fathi organization: Alexandria University – sequence: 2 givenname: Osama Hussein surname: Roshdy fullname: Roshdy, Osama Hussein organization: Alexandria University – sequence: 3 givenname: Rania ElSaied surname: Abdelmaksoud fullname: Abdelmaksoud, Rania ElSaied organization: Alexandria University – sequence: 4 givenname: Dina Mohamed surname: Abdalla fullname: Abdalla, Dina Mohamed organization: Alexandria University – sequence: 5 givenname: Iman Mamdouh surname: Talaat fullname: Talaat, Iman Mamdouh organization: University of Sharjah – sequence: 6 givenname: Eiman Ibrahim surname: Zaki fullname: Zaki, Eiman Ibrahim organization: Alexandria University – sequence: 7 givenname: Amira surname: El Tawdy fullname: El Tawdy, Amira organization: Cairo University – sequence: 8 givenname: Bodo C. orcidid: 0000-0002-4501-1809 surname: Melnik fullname: Melnik, Bodo C. email: melnik@t-online.de organization: University of Osnabrück |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30240097$$D View this record in MEDLINE/PubMed |
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| Keywords | isotretinoin acne sebocyte apoptosis FoxOs |
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| Snippet | Oral isotretinoin is the most effective anti‐acne drug with the strongest sebum‐suppressive effect caused by sebocyte apoptosis. It has been hypothesized that... Oral isotretinoin is the most effective anti-acne drug with the strongest sebum-suppressive effect caused by sebocyte apoptosis. It has been hypothesized that... Abstract Oral isotretinoin is the most effective anti‐acne drug with the strongest sebum‐suppressive effect caused by sebocyte apoptosis. It has been... |
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| SubjectTerms | Acne Apoptosis Forkhead protein FOXO1 protein FOXO3 protein FoxOs isotretinoin p53 Protein Patients Proteins Sebaceous gland sebocyte apoptosis Skin Transcription factors |
| Title | Effect of oral isotretinoin on the nucleo‐cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris |
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