Mesenchymal stem cells‐derived IL‐6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK‐STAT3 signalling

• Published in: Oral diseases Vol. 30; no. 4; pp. 2097 - 2109
• Main Authors: Liu, Chuanxia, Zhou, Jinhan, Zhang, Shanshan, Fu, Ji, Li, Yining, Hao, Yilong, Yuan, Jian, Tang, Fan, Ge, Weili, He, Hong, Chen, Qianming
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.05.2024
• Subjects: Animals; Antibodies, Monoclonal, Humanized - pharmacology; Antibodies, Monoclonal, Humanized - therapeutic use; cancer progression; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - secondary; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cytokines; Epithelial-Mesenchymal Transition; Female; Humans; Interleukin 6; Interleukin-6 - metabolism; Janus Kinases - metabolism; Lymph nodes; Male; Malignancy; Medical diagnosis; Medical prognosis; mesenchymal stem cell; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Metastases; Metastasis; Mice; Mice, Nude; Molecular modelling; Monoclonal antibodies; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Neoplasm Invasiveness; Neoplasm Metastasis; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; Signal Transduction; Squamous cell carcinoma; Stat3 protein; STAT3 Transcription Factor - metabolism; Stem cells; Survival analysis; Tumors; Xenografts; interleukin 6; mesenchymal stem cell; oral squamous cell carcinoma; cancer progression; metastasis

Objectives Oral squamous cell carcinoma (OSCC) is often diagnosed with cervical lymph node metastasis. Mesenchymal stem cells (MSCs) and interleukin‐6 (IL‐6) signalling are considered to play important roles in promoting tumour malignancy. The detailed biological interaction of MSCs and IL‐6 and the...