Driver mutations of young lung adenocarcinoma patients with malignant pleural effusion

• Published in: Genes chromosomes & cancer Vol. 57; no. 10; pp. 513 - 521
• Main Authors: Wu, Shang‐Gin, Liu, Yi‐Nan, Yu, Chong‐Jen, Yang, James Chih‐Hsin, Shih, Jin‐Yuan
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.10.2018; Wiley Subscription Services, Inc
• Subjects: Adenocarcinoma; Adenocarcinoma - complications; Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; AKT2 protein; Asian Continental Ancestry Group - genetics; DNA Mutational Analysis; Effusion; EGFR; Epidermal growth factor receptors; ErbB-2 protein; Female; Health risk assessment; Humans; Janus kinase 2; Lung cancer; Lung Neoplasms - complications; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Lungs; Male; Middle Aged; Mutation; Mutation rates; Oncogene Proteins, Fusion - genetics; Pleural effusion; Pleural Effusion, Malignant - complications; Pleural Effusion, Malignant - genetics; Pleural Effusion, Malignant - pathology; Point mutation; Polymerase chain reaction; Population genetics; Protein-Tyrosine Kinases - genetics; Proto-Oncogene Proteins - genetics; Reverse transcription; Ribonucleic acid; RNA; Smoking; TKI; young patients; lung cancer; mutation; TKI; young patients; EGFR
• ISSN: 1045-2257; 1098-2264; 1098-2264
• DOI: 10.1002/gcc.22647

Young lung cancer patients have several distinct characteristics. However, there are limited epidemiological data of genetic abnormalities in this population. We conducted a prospective cohort study to delineate the various oncogenic driver mutations of lung adenocarcinoma in young Asian patients. W...