LncRNA–CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA‐215

• Published in: Journal of cellular physiology Vol. 234; no. 6; pp. 9105 - 9117
• Main Authors: Kong, Xiaoli, Duan, Yi, Sang, Yuting, Li, Yaming, Zhang, Hanwen, Liang, Yiran, Liu, Ying, Zhang, Ning, Yang, Qifeng
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2019
• Subjects: Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell division; Cell Movement; Cell Proliferation; Disease Progression; Ectopic expression; Female; G1 phase; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; lncRNA–CDC6; MCF-7 Cells; Metastases; Metastasis; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; miR‐215; Neoplasm Invasiveness; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; proliferation; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Signal Transduction; Tumors; breast cancer; miR-215; proliferation; metastasis; lncRNA-CDC6

Rapid proliferation and metastasis of breast cancers resulted in poor prognosis in clinic. Recent studies have proved that long noncoding RNAs (lncRNAs) were involved in tumor progression. In this study, we aimed to determine the roles and mechanisms of lncRNA–cell division cycle 6 (CDC6) in regulat...